TY - JOUR
T1 - The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker
T2 - Study design and protocol
AU - For the EpiBioS4Rx Study Group
AU - Vespa, Paul M.
AU - Shrestha, Vikesh
AU - Abend, Nicholas
AU - Agoston, Denes
AU - Au, Alicia
AU - Bell, Michael J.
AU - Bleck, Thomas P.
AU - Blanco, Manuel Buitrago
AU - Claassen, Jan
AU - Diaz-Arrastia, Ramon
AU - Duncan, Dominique
AU - Ellingson, Ben
AU - Foreman, Brandon
AU - Gilmore, Emily J.
AU - Hirsch, Lawrence
AU - Hunn, Martin
AU - Kamnaksh, Alaa
AU - McArthur, David
AU - Morokoff, Andrew
AU - O'Brien, Terrence
AU - O'Phelan, Kristine
AU - Robertson, Courtney L.
AU - Rosenthal, Eric
AU - Staba, Richard
AU - Toga, Arthur
AU - Willyerd, Frederick A.
AU - Zimmermann, Lara
AU - Yam, Elisa
AU - Martinez, Susana
AU - Real, Courtney
AU - Engel, Jerome
AU - Bleck Thomas, P.
AU - Branch, Craig
AU - Buitrago Blanco, Manuel
AU - Bullock, Ross
AU - Burrows, Brian T.
AU - Clarke, Robert
AU - Cloyd, James
AU - Coles, Lisa
AU - Crawford, Karen
AU - Ellingson, Benjamin
AU - Galanopoulou, Aristea
AU - Gilmore, Emily
AU - Grohn, Olli
AU - Harris, Neil
AU - Hartings, Jed
AU - Lawrence, Hirsch
AU - Jette, Nathalie
AU - Moshe, Solomon
AU - Mowrey, Wenzhu
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/3
Y1 - 2019/3
N2 - The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.
AB - The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.
UR - http://www.scopus.com/inward/record.url?scp=85050387436&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050387436&partnerID=8YFLogxK
U2 - 10.1016/j.nbd.2018.07.025
DO - 10.1016/j.nbd.2018.07.025
M3 - Review article
C2 - 30048805
AN - SCOPUS:85050387436
SN - 0969-9961
VL - 123
SP - 110
EP - 114
JO - Neurobiology of Disease
JF - Neurobiology of Disease
ER -