TY - JOUR
T1 - The effects of two new inotropic agents on microsomal liver function in patients with congestive heart failure
AU - Manzione, N. C.
AU - Goldfarb, J. P.
AU - LeJemtel, T. H.
AU - Maskin, C. S.
AU - Sternlieb, I.
N1 - Funding Information:
From the Divisions of Gastroenter ology-Liver Diseases, Cardiology and Liver Research Center, AlbertEinstein College of Medicine, Bronx, New York. The authors thank Anna Caponigro for her excellent secretarial assistance. Supported in parts by grants from the Sterling Winthrop Research Institute, Rensselaer, and the National Institutes of Health AM -07218 and AM -17702. Reprints requests: Nancy C. Manzione, MD, Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461.
PY - 1986
Y1 - 1986
N2 - The aminopyrine breath test (APBT) was used to study patients with chronic congestive heart failure before and after treatment with two chemically similar inotropic agents, amrinone (AR) and milrinone (MR), to determine their effects on hepatic microsomal function. Liver chemistries and cardiac indices were measured and correlated with the 2-hour APBT score in 11 patients with chronic congestive heart failure (5 treated with AR, 6 with MR) and five healthy control subjects. Despite normal or near-normal liver chemistries, patients with chronic congestive heart failure demonstrated overall depressed hepatic microsomal oxidative function. Patients with severe congestive heart failure had a lower mean pretreatment APBT score (AR = 3.05 ± 1.02, MR = 5.38 ± 3.09) when compared with healthy controls (10.02 ± 1.02). However, the APBT score for each individual could not be predicted from the cardiac index. Although the mean cardiac index increased significantly in both the AR and the MR treated patients by 26.14% ± 15.28 (p < 0.01) and 40.0% ± 42.27 (p < 0.025), respectively, compared with pretreatment values, the mean APBT score fell by 62.02% ± 22.5 (p < 0.005) in the former and increased by 38.35% ± 25.69 (p < 0.01) in the patients receiving MR. This discordance between the effects of AR and MR suggests possible differences in the effects of the two drugs on hepatic microsomal function.
AB - The aminopyrine breath test (APBT) was used to study patients with chronic congestive heart failure before and after treatment with two chemically similar inotropic agents, amrinone (AR) and milrinone (MR), to determine their effects on hepatic microsomal function. Liver chemistries and cardiac indices were measured and correlated with the 2-hour APBT score in 11 patients with chronic congestive heart failure (5 treated with AR, 6 with MR) and five healthy control subjects. Despite normal or near-normal liver chemistries, patients with chronic congestive heart failure demonstrated overall depressed hepatic microsomal oxidative function. Patients with severe congestive heart failure had a lower mean pretreatment APBT score (AR = 3.05 ± 1.02, MR = 5.38 ± 3.09) when compared with healthy controls (10.02 ± 1.02). However, the APBT score for each individual could not be predicted from the cardiac index. Although the mean cardiac index increased significantly in both the AR and the MR treated patients by 26.14% ± 15.28 (p < 0.01) and 40.0% ± 42.27 (p < 0.025), respectively, compared with pretreatment values, the mean APBT score fell by 62.02% ± 22.5 (p < 0.005) in the former and increased by 38.35% ± 25.69 (p < 0.01) in the patients receiving MR. This discordance between the effects of AR and MR suggests possible differences in the effects of the two drugs on hepatic microsomal function.
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U2 - 10.1097/00000441-198602000-00003
DO - 10.1097/00000441-198602000-00003
M3 - Article
C2 - 3946472
AN - SCOPUS:0022877251
SN - 0002-9629
VL - 291
SP - 88
EP - 92
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 2
ER -