The effects of organophosphate pesticides on mitochondria

Saeed Samarghandian; Tahereh Farkhondeh; Milad Ashrafizadeh; Marjan Talebi; Michael Aschner; Majid Darroudi

doi:10.1016/B978-0-323-88462-4.00024-9

The effects of organophosphate pesticides on mitochondria

Saeed Samarghandian
, Tahereh Farkhondeh
, Milad Ashrafizadeh
, Marjan Talebi
, Michael Aschner
, Majid Darroudi

Molecular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

6 Scopus citations

Abstract

Organophosphates (OPs) are an important class of toxic agents that are applied for controlling pests. Toxic effects of OPs have been found at concentrations below inhibition of acetylcholinesterase (AChE). OPs are able to cause damage in various tissues, leading to acute and chronic diseases. A limited number of OPs are able to directly bind to cholinesterases in the parent form. Mitochondria is the main target for adverse effects of OPs. Mitochondria has a main role in the toxicity of OPs by inducing reactive oxygen species production that plays as signaling molecules that is considered as a non-cholinergic mechanism of OPs toxicity. Redox signaling regulates proliferation, differentiation, and function in the cells. Several experimental studies have indicated that exposure to OPs causes oxidative stress due to mitochondrial dysfunction.

Original language	English (US)
Title of host publication	Mitochondrial Intoxication
Publisher	Elsevier
Pages	587-600
Number of pages	14
ISBN (Electronic)	9780323884624
DOIs	https://doi.org/10.1016/B978-0-323-88462-4.00024-9
State	Published - Jan 1 2022

Keywords

Mitochondria
Organophosphate pesticides
Oxidative stress
Toxicity

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/B978-0-323-88462-4.00024-9

Cite this

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title = "The effects of organophosphate pesticides on mitochondria",

abstract = "Organophosphates (OPs) are an important class of toxic agents that are applied for controlling pests. Toxic effects of OPs have been found at concentrations below inhibition of acetylcholinesterase (AChE). OPs are able to cause damage in various tissues, leading to acute and chronic diseases. A limited number of OPs are able to directly bind to cholinesterases in the parent form. Mitochondria is the main target for adverse effects of OPs. Mitochondria has a main role in the toxicity of OPs by inducing reactive oxygen species production that plays as signaling molecules that is considered as a non-cholinergic mechanism of OPs toxicity. Redox signaling regulates proliferation, differentiation, and function in the cells. Several experimental studies have indicated that exposure to OPs causes oxidative stress due to mitochondrial dysfunction.",

keywords = "Mitochondria, Organophosphate pesticides, Oxidative stress, Toxicity",

author = "Saeed Samarghandian and Tahereh Farkhondeh and Milad Ashrafizadeh and Marjan Talebi and Michael Aschner and Majid Darroudi",

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TY - CHAP

T1 - The effects of organophosphate pesticides on mitochondria

AU - Samarghandian, Saeed

AU - Farkhondeh, Tahereh

AU - Ashrafizadeh, Milad

AU - Talebi, Marjan

AU - Aschner, Michael

AU - Darroudi, Majid

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Organophosphates (OPs) are an important class of toxic agents that are applied for controlling pests. Toxic effects of OPs have been found at concentrations below inhibition of acetylcholinesterase (AChE). OPs are able to cause damage in various tissues, leading to acute and chronic diseases. A limited number of OPs are able to directly bind to cholinesterases in the parent form. Mitochondria is the main target for adverse effects of OPs. Mitochondria has a main role in the toxicity of OPs by inducing reactive oxygen species production that plays as signaling molecules that is considered as a non-cholinergic mechanism of OPs toxicity. Redox signaling regulates proliferation, differentiation, and function in the cells. Several experimental studies have indicated that exposure to OPs causes oxidative stress due to mitochondrial dysfunction.

AB - Organophosphates (OPs) are an important class of toxic agents that are applied for controlling pests. Toxic effects of OPs have been found at concentrations below inhibition of acetylcholinesterase (AChE). OPs are able to cause damage in various tissues, leading to acute and chronic diseases. A limited number of OPs are able to directly bind to cholinesterases in the parent form. Mitochondria is the main target for adverse effects of OPs. Mitochondria has a main role in the toxicity of OPs by inducing reactive oxygen species production that plays as signaling molecules that is considered as a non-cholinergic mechanism of OPs toxicity. Redox signaling regulates proliferation, differentiation, and function in the cells. Several experimental studies have indicated that exposure to OPs causes oxidative stress due to mitochondrial dysfunction.

KW - Mitochondria

KW - Organophosphate pesticides

KW - Oxidative stress

KW - Toxicity

UR - https://www.scopus.com/pages/publications/85161041856

UR - https://www.scopus.com/pages/publications/85161041856#tab=citedBy

U2 - 10.1016/B978-0-323-88462-4.00024-9

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M3 - Chapter

AN - SCOPUS:85161041856

SP - 587

EP - 600

BT - Mitochondrial Intoxication

PB - Elsevier

ER -

The effects of organophosphate pesticides on mitochondria

Abstract

Keywords

ASJC Scopus subject areas

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