TY - JOUR
T1 - The effect of World Trade Center exposure on the latency of chronic rhinosinusitis diagnoses in New York City firefighters
T2 - 2001-2011
AU - Weakley, Jessica
AU - Hall, Charles B.
AU - Liu, Xiaoxue
AU - Zeig-Owens, Rachel
AU - Webber, Mayris P.
AU - Schwartz, Theresa
AU - Prezant, David
PY - 2016/4
Y1 - 2016/4
N2 - Objective To assess how the effect of World Trade Center (WTC) exposure on physician-diagnosed chronic rhinosinusitis (CRS) in firefighters changed during the decade following the attack on 9/11 (11 September 2001 to 10 September 2011). Methods We examined temporal effects on the relation between WTC exposure and the incidence of physician diagnosed CRS in firefighters changed during the decade following the attack on 9/11 (11 September 2001 to 10 September 2011). Exposure was grouped by time of arrival at the WTC site as follows: (high) morning 11 September 2001 (n=1623); (moderate) afternoon 11 September 2001 or 12 September 2001 (n=7025); or (low) 13-24 September 2001 (n=1200). Piecewise exponential survival models were used to estimate incidences by exposure group, with change points in the relative incidences estimated by maximum likelihood. Results Incidences dramatically increased after 2007 due to a programmatic change that provided free medical treatment, but increases were similar in all exposure groups. For this reason, we observed no change point during the study period, meaning the relative incidence by exposure group (high vs moderate vs low) of CRS disease did not significantly change over the study period. The relative rate of developing CRS was 1.99 (95% CI=1.64 to 2.41) for high versus low exposure, and 1.52 (95% CI=1.28 to 1.80) for moderate versus low exposure during the 10-year followup period. Conclusions The risk of CRS in FDNY firefighters appears increased with WTC-exposure, and has not diminished by time since exposure.
AB - Objective To assess how the effect of World Trade Center (WTC) exposure on physician-diagnosed chronic rhinosinusitis (CRS) in firefighters changed during the decade following the attack on 9/11 (11 September 2001 to 10 September 2011). Methods We examined temporal effects on the relation between WTC exposure and the incidence of physician diagnosed CRS in firefighters changed during the decade following the attack on 9/11 (11 September 2001 to 10 September 2011). Exposure was grouped by time of arrival at the WTC site as follows: (high) morning 11 September 2001 (n=1623); (moderate) afternoon 11 September 2001 or 12 September 2001 (n=7025); or (low) 13-24 September 2001 (n=1200). Piecewise exponential survival models were used to estimate incidences by exposure group, with change points in the relative incidences estimated by maximum likelihood. Results Incidences dramatically increased after 2007 due to a programmatic change that provided free medical treatment, but increases were similar in all exposure groups. For this reason, we observed no change point during the study period, meaning the relative incidence by exposure group (high vs moderate vs low) of CRS disease did not significantly change over the study period. The relative rate of developing CRS was 1.99 (95% CI=1.64 to 2.41) for high versus low exposure, and 1.52 (95% CI=1.28 to 1.80) for moderate versus low exposure during the 10-year followup period. Conclusions The risk of CRS in FDNY firefighters appears increased with WTC-exposure, and has not diminished by time since exposure.
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U2 - 10.1136/oemed-2015-103094
DO - 10.1136/oemed-2015-103094
M3 - Article
C2 - 26574577
AN - SCOPUS:84961843529
SN - 1351-0711
VL - 73
SP - 280
EP - 283
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
IS - 4
ER -