Abstract
We investigated a bridging protocol using oral Vitamin K three days before scheduled surgery. 60 patients in two bridging protocols, 30 cases per protocol. The first cohort (Control group) had its warfarin held on Day-5 (five days before surgery). The intervention cohort (Vitamin K group) routinely received 2.5 mg of oral Vitamin K on Day-3 but was otherwise identically bridged. Primary outcome was INR on Day-1. Secondary outcomes included patients with INRs ≥1.5 on Day-1, bleeding episodes and elevated INR post surgery. Day-1 INR for the Vitamin K group was 1.16, vs. 1.28 for the Control group (p = 0.037). Postoperative INR was similar. Only the Control group had patients with INRs ≥1.5 on Day-1, or patients with significant bleeding. Adding Vitamin K on Day-3 leads to a safe preoperative INR and may limit other complications.
Original language | English (US) |
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Pages (from-to) | 264-267 |
Number of pages | 4 |
Journal | International journal of hematology |
Volume | 101 |
Issue number | 3 |
DOIs | |
State | Published - Mar 6 2015 |
Keywords
- Anticoagulation
- Bridging therapy
- Vitamin K
ASJC Scopus subject areas
- Hematology