Abstract
This study determined the effect of in utero hypoxia on fetal heart and brain pro- and antioxidant trace metals. Dunkin-Hartley guinea pigs (50-60 days gestation) were exposed to 1 h hypoxia (7% O2/93% N2) followed by 4 h reoxygenation in room air. Fetal hearts and brains were harvested and analyzed for copper, iron, magnesium and zinc. Fetal brain iron was significantly increased 28% after hypoxia and 35% by 1 h posthypoxia. Fetal brain magnesium demonstrated progressive decreases of 18% by 4 h posthypoxia. No significant effects of hypoxia were observed on heart trace metals. These results indicate that prooxidant metals may be increased and antioxidant metals may be decreased in posthypoxic fetal brain during a time when these tissues may be vulnerable to oxidative injury.
Original language | English (US) |
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Pages (from-to) | 245-248 |
Number of pages | 4 |
Journal | Journal of Trace Elements in Medicine and Biology |
Volume | 16 |
Issue number | 4 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
Keywords
- Brain
- Fetal hypoxia
- Heart
- Magnesium
- Trace metals
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Inorganic Chemistry