The Effect of Constipation on Valproic Acid Dosage in a 17-Year-Old

Jennifer E. Madan Cohen; Solomon L. Moshe

doi:10.1016/j.pediatrneurol.2008.10.008

The Effect of Constipation on Valproic Acid Dosage in a 17-Year-Old

Jennifer E. Madan Cohen, Solomon L. Moshe

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

Although valproic acid absorption measurements have been reported for animal models, there have been no reports that correlate this to clinical experience with a patient. Reported here is the case of a patient who required twice the dose of valproic acid after colostomy for chronic constipation. The increased dosage required may have been due to rapid intestinal transit time or to bypass of the left colon. This case highlights the importance of gastrointestinal function in patients on valproic acid therapy.

Original language	English (US)
Pages (from-to)	126-127
Number of pages	2
Journal	Pediatric Neurology
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/j.pediatrneurol.2008.10.008
State	Published - Feb 2009

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Neurology
Developmental Neuroscience
Clinical Neurology

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10.1016/j.pediatrneurol.2008.10.008

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title = "The Effect of Constipation on Valproic Acid Dosage in a 17-Year-Old",

abstract = "Although valproic acid absorption measurements have been reported for animal models, there have been no reports that correlate this to clinical experience with a patient. Reported here is the case of a patient who required twice the dose of valproic acid after colostomy for chronic constipation. The increased dosage required may have been due to rapid intestinal transit time or to bypass of the left colon. This case highlights the importance of gastrointestinal function in patients on valproic acid therapy.",

author = "{Madan Cohen}, {Jennifer E.} and Moshe, {Solomon L.}",

note = "Funding Information: This work was supported in part by the Heffer Family Foundation. S.L.M. is the recipient of a Martin A. and Emily L. Fisher fellowship in Neurology and Pediatrics. ",

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AB - Although valproic acid absorption measurements have been reported for animal models, there have been no reports that correlate this to clinical experience with a patient. Reported here is the case of a patient who required twice the dose of valproic acid after colostomy for chronic constipation. The increased dosage required may have been due to rapid intestinal transit time or to bypass of the left colon. This case highlights the importance of gastrointestinal function in patients on valproic acid therapy.

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The Effect of Constipation on Valproic Acid Dosage in a 17-Year-Old

Abstract

ASJC Scopus subject areas

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