The Effect of Constipation on Valproic Acid Dosage in a 17-Year-Old

Jennifer E. Madan Cohen, Solomon L. Moshe

Research output: Contribution to journalArticlepeer-review


Although valproic acid absorption measurements have been reported for animal models, there have been no reports that correlate this to clinical experience with a patient. Reported here is the case of a patient who required twice the dose of valproic acid after colostomy for chronic constipation. The increased dosage required may have been due to rapid intestinal transit time or to bypass of the left colon. This case highlights the importance of gastrointestinal function in patients on valproic acid therapy.

Original languageEnglish (US)
Pages (from-to)126-127
Number of pages2
JournalPediatric Neurology
Issue number2
StatePublished - Feb 2009

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology


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