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The effect of colchicine on guinea pig intestinal enzyme activity

  • Michael I. Cohen
  • , Helen McNamara

Research output: Contribution to journalArticlepeer-review

Abstract

The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalAmerican Journal of Digestive Diseases
Volume15
Issue number3
DOIs
StatePublished - Mar 1970

ASJC Scopus subject areas

  • Gastroenterology

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