Abstract
Chronic neurodegenerative disorders and acute injuries of the central nervous system exert a prohibitive economic burden, which is aggravated by an unmet medical need for the development of effective neurotherapeutics. The evolutionarily conserved neuropeptide, adrenomedullin (AM), and its binding protein, AMBP-1, also known as complement factor H, play important roles in brain physiology, and their expression is altered in brain pathology. In this review, we discuss the molecular regulation of AM and AMBP-1 and the pivotal roles they play in neuroprotection following brain injury. We assess the reciprocal synergistic effects of AM and AMBP-1 and make suggestions for the design of a novel combination neurotherapy devoid of the potential hypotensive effects of AM while optimizing its neuroprotective property.
Original language | English (US) |
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Pages (from-to) | 429-439 |
Number of pages | 11 |
Journal | Biological Chemistry |
Volume | 393 |
Issue number | 6 |
DOIs | |
State | Published - May 2012 |
Externally published | Yes |
Keywords
- AMBP-1
- adrenomedullin
- apoptosis
- inflammation
- neurodegenerative disease
- neuroprotection
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Clinical Biochemistry