The complex associations between obstructive sleep apnea and auto-immune disorders: A review

Mayand Vakil; Steven Park; Anna Broder

doi:10.1016/j.mehy.2017.12.004

The complex associations between obstructive sleep apnea and auto-immune disorders: A review

Mayand Vakil, Steven Park, Anna Broder

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Obstructive sleep apnea is known to be associated with diseases such as hypertension, metabolic disorder, and cancer. A more controversial and less understood association is that of sleep apneas and the development and worsening of autoimmune and rheumatologic disorders. Through the main pathways of intermittent hypoxia and sleep deprivation, we hypothesize that obstructive sleep apnea creates a chronic inflammatory state that worsens or incites autoimmune disorders. This thorough review of the available literature highlights our current understanding of the relationship between these disease processes in order to demonstrate the importance of diagnosis and appropriate management of sleep disorders in patients suffering from rheumatologic diseases.

Original language	English (US)
Pages (from-to)	138-143
Number of pages	6
Journal	Medical Hypotheses
Volume	110
DOIs	https://doi.org/10.1016/j.mehy.2017.12.004
State	Published - Jan 2018

Keywords

Chronic inflammation
Intermittent hypoxia
Neuro-inflammation
Obesity
Obstructive sleep apnea
Psoriasis
Raynaud's phenomenon
Rheumatoid arthritis
Sleep deprivation
Systemic lupus erythematosus

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mehy.2017.12.004

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title = "The complex associations between obstructive sleep apnea and auto-immune disorders: A review",

abstract = "Obstructive sleep apnea is known to be associated with diseases such as hypertension, metabolic disorder, and cancer. A more controversial and less understood association is that of sleep apneas and the development and worsening of autoimmune and rheumatologic disorders. Through the main pathways of intermittent hypoxia and sleep deprivation, we hypothesize that obstructive sleep apnea creates a chronic inflammatory state that worsens or incites autoimmune disorders. This thorough review of the available literature highlights our current understanding of the relationship between these disease processes in order to demonstrate the importance of diagnosis and appropriate management of sleep disorders in patients suffering from rheumatologic diseases.",

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AB - Obstructive sleep apnea is known to be associated with diseases such as hypertension, metabolic disorder, and cancer. A more controversial and less understood association is that of sleep apneas and the development and worsening of autoimmune and rheumatologic disorders. Through the main pathways of intermittent hypoxia and sleep deprivation, we hypothesize that obstructive sleep apnea creates a chronic inflammatory state that worsens or incites autoimmune disorders. This thorough review of the available literature highlights our current understanding of the relationship between these disease processes in order to demonstrate the importance of diagnosis and appropriate management of sleep disorders in patients suffering from rheumatologic diseases.

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KW - Sleep deprivation

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The complex associations between obstructive sleep apnea and auto-immune disorders: A review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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