TY - JOUR
T1 - The aging brain
T2 - impact of heavy metal neurotoxicity
AU - Ijomone, Omamuyovwi M.
AU - Ifenatuoha, Chibuzor W.
AU - Aluko, Oritoke M.
AU - Ijomone, Olayemi K.
AU - Aschner, Michael
N1 - Funding Information:
This work was supported by the International Brain Research Organization (IBRO) and National Institute of Health (NIH), respectively [to OMI and MA]. OMI acknowledges the Young IBRO Regions Connecting Awards toward collaborative activities between The Neuro- Lab, Federal University of Technology Akure, Nigeria, and Aschner’s Lab, Albert Einstein College of Medicine, USA. MA is supported by National Institute of Health (NIH), USA [grant number NIEHS R01 10563], grant number NIEHS R01 07331], [grant number NIEHS R01 020852]. The authors gratefully acknowledge the valuable and extensive critiques of the three anonymous reviewers that were selected by the Editor. Also, we acknowledge the vital feedback received from the Editor. These critiques were very helpful in revising and improving the manuscript.
Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020
Y1 - 2020
N2 - The aging process is accompanied by critical changes in cellular and molecular functions, which upset the homeostatic balance in the central nervous system. Accumulation of metals renders the brain susceptible to neurotoxic insults by mechanisms such as mitochondrial dysfunction, neuronal calcium-ion dyshomeostasis, buildup of damaged molecules, compromised DNA repair, reduction in neurogenesis, and impaired energy metabolism. These hallmarks have been identified to be responsible for neuronal injuries, resulting in several neurological disorders. Various studies have shown solid associations between metal accumulation, abnormal protein expressions, and pathogenesis of neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and Amyotrophic lateral sclerosis. This review highlights metals (such as manganese, zinc, iron, copper, and nickel) for their accumulation, and consequences in the development of neurological disorders, in relation to the aging brain.
AB - The aging process is accompanied by critical changes in cellular and molecular functions, which upset the homeostatic balance in the central nervous system. Accumulation of metals renders the brain susceptible to neurotoxic insults by mechanisms such as mitochondrial dysfunction, neuronal calcium-ion dyshomeostasis, buildup of damaged molecules, compromised DNA repair, reduction in neurogenesis, and impaired energy metabolism. These hallmarks have been identified to be responsible for neuronal injuries, resulting in several neurological disorders. Various studies have shown solid associations between metal accumulation, abnormal protein expressions, and pathogenesis of neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and Amyotrophic lateral sclerosis. This review highlights metals (such as manganese, zinc, iron, copper, and nickel) for their accumulation, and consequences in the development of neurological disorders, in relation to the aging brain.
KW - DNA damage oxidative stress
KW - Neurotoxicity
KW - aging
KW - brain diseases
KW - metal accumulation
KW - mitochondrial dysfunction
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U2 - 10.1080/10408444.2020.1838441
DO - 10.1080/10408444.2020.1838441
M3 - Review article
C2 - 33210961
AN - SCOPUS:85096383536
SN - 1040-8444
VL - 50
SP - 801
EP - 814
JO - Critical reviews in toxicology
JF - Critical reviews in toxicology
IS - 9
ER -