The adrenal cortex in adreno leukodystrophy

J. M. Powers, H. H. Schaumburg

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


The adrenal glands from 9 patients with hereditary adreno leukodystrophy were studied. Unique changes were found in the zona fasciculata and reticularis in 8 of the cases. These changes consisted of ballooned cortical cells, many of which had a striated cytoplasm with macrovacuoles. This spectrum of change suggests that the evolution of adrenal atrophy in this disease is a primary adrenolytic process. An autoimmune process, previously proposed in this condition, now seems unlikely.

Original languageEnglish (US)
Pages (from-to)305-310
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Issue number5
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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