Temperature sensitive liposome encapsulated adriamycin combined with hepatic artery embolization

A temperature sensitive liposome composed of a vesicle membrane of dipalmitoyl phosphatidylcholine and encapsulated adriamycin was made by the modified reverse-phase evaporation method. The encapsulation efficiency measured with a centrifugal filtration method was about 38%. The phase-transition temperature of the liposome determined by DSC was 41 degrees C. The liposome size was 851 +/- 50 nm, and the size distribution was from 772 to 952 nm as measured by laser particle analyzer with dynamic light scatter method. Eighty-four percent of the encapsulated drug could be released at precisely the phase-transition temperature of liposome in vitro. The results show that the liposomal drug is sensitive to temperature-controlled release.