Abstract
Exposure of organotypic mouse spinal cord-dorsal root ganglion cultures to 1-2 μM taxol for up to 6 days results in a remarkable increase in cytoplasmic microtubules in differentiated oligodendroglia. In contrast, there is a notably smaller change in the microtubule compliment of astroglia. This suggests that the regulatory and/or synthetic systems for tubulin in these glial types may differ, and that oligodendroglia appear more responsive to modulation in the levels of tubulin subunits as a result of the action of taxol.
Original language | English (US) |
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Pages (from-to) | 539-546 |
Number of pages | 8 |
Journal | Cell Biology International Reports |
Volume | 9 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1985 |
ASJC Scopus subject areas
- Cell Biology