Targeting signal transduction pathways in hematopoietic disorders

Li Zhou; Amit Verma

doi:10.1007/978-0-387-85816-6_11

Targeting signal transduction pathways in hematopoietic disorders

Li Zhou
, Amit Verma

Oncology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Hematopoiesis is the process during which pluripotent stem cells give rise to lineage committed progenitors that differentiate into mature erythroid, myeloid, and lymphoid cells. This is a finely regulated process that is required for optimal maintenance of peripheral blood counts. Alterations in hematopoiesis can lead to a variety of bone marrow failure syndromes and hematological malignancies. Treatment of these diseases requires a detailed study of pathogenic mechanisms that lead to hematopoietic failure.

Original language	English (US)
Title of host publication	Molecular Basis of Hematopoiesis
Publisher	Springer New York
Pages	231-252
Number of pages	22
ISBN (Print)	9780387858159
DOIs	https://doi.org/10.1007/978-0-387-85816-6_11
State	Published - 2009

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-0-387-85816-6_11

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abstract = "Hematopoiesis is the process during which pluripotent stem cells give rise to lineage committed progenitors that differentiate into mature erythroid, myeloid, and lymphoid cells. This is a finely regulated process that is required for optimal maintenance of peripheral blood counts. Alterations in hematopoiesis can lead to a variety of bone marrow failure syndromes and hematological malignancies. Treatment of these diseases requires a detailed study of pathogenic mechanisms that lead to hematopoietic failure.",

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AB - Hematopoiesis is the process during which pluripotent stem cells give rise to lineage committed progenitors that differentiate into mature erythroid, myeloid, and lymphoid cells. This is a finely regulated process that is required for optimal maintenance of peripheral blood counts. Alterations in hematopoiesis can lead to a variety of bone marrow failure syndromes and hematological malignancies. Treatment of these diseases requires a detailed study of pathogenic mechanisms that lead to hematopoietic failure.

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M3 - Chapter

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BT - Molecular Basis of Hematopoiesis

PB - Springer New York

ER -

Targeting signal transduction pathways in hematopoietic disorders

Abstract

ASJC Scopus subject areas

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