Abstract
Recent studies in the field of CD8+ Tregs have allowed a better identification and characterization of this subset of regulatory cells. Their key role in the regulation of allogeneic responses is now well established. To take full advantage of CD8+ Treg cells in future therapeutic applications, a better knowledge is required, particularly concerning the contribution of the T-cell receptor (TCR) in cell function as well as the role and importance of its antigenic specificity. Here, we focused on the CD8 +CD45RClow Tregs, which in rats induce an indefinite long-term allograft acceptance. We summarized recent findings on their interaction properties with antigen-presenting cells. Identification of the antigenic targets and TCR repertoire of CD8+ Tregs will allow a better understanding of their recognition properties and will highlight the potential of such of specific population in cell-based treatment.
Original language | English (US) |
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Pages (from-to) | 35-37 |
Number of pages | 3 |
Journal | Immunotherapy |
Volume | 3 |
Issue number | 4 SUPPL. |
DOIs | |
State | Published - Apr 2011 |
Externally published | Yes |
Keywords
- CD8 regulatory T cells
- TCR
- antigen specificity
- tolerance
- transplantation
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology