T-cell receptor isoforms and signal transduction

Shigeo Koyasu, Luciano D'Adamio, Linda K. Clayton, Ellis L. Reinherz

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Recent cDNA and genomic cloning have identified CD3Tη as an alternatively spliced product of the same gene locus that encodes CD3ζ. Three distinct T-cell receptor isoforms have now been identified. A current view of the signal transduction function of these isoforms in thymocytes and T cells is discussed.

Original languageEnglish (US)
Pages (from-to)32-39
Number of pages8
JournalCurrent Opinion in Immunology
Issue number1
StatePublished - 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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