Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases

Gary B. Evans; Richard H. Furneaux; Graeme J. Gainsford; Vern L. Schramm; Peter C. Tyler

doi:10.1016/S0040-4020(00)00194-0

Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases

Gary B. Evans
, Richard H. Furneaux
, Graeme J. Gainsford
, Vern L. Schramm
, Peter C. Tyler

Biochemistry

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Syntheses of the 'Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5- deoxyfluoro- and 2-deoxy- analogues and others having modified bases. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	3053-3062
Number of pages	10
Journal	Tetrahedron
Volume	56
Issue number	19
DOIs	https://doi.org/10.1016/S0040-4020(00)00194-0
State	Published - May 5 2000

Keywords

Carbohydrate mimetics
Enzyme inhibitors
Nucleosides
Purines

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4020(00)00194-0

Cite this

@article{cb7bcdd32d9f4cdd8d9a655edec28bef,

title = "Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases",

abstract = "Syntheses of the 'Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5- deoxyfluoro- and 2-deoxy- analogues and others having modified bases. (C) 2000 Elsevier Science Ltd.",

keywords = "Carbohydrate mimetics, Enzyme inhibitors, Nucleosides, Purines",

author = "Evans, \{Gary B.\} and Furneaux, \{Richard H.\} and Gainsford, \{Graeme J.\} and Schramm, \{Vern L.\} and Tyler, \{Peter C.\}",

note = "Funding Information: The authors thank Dr Herbert Wong for an excellent NMR service and Professor Robin Ferrier for assisting with the preparation of the manuscript. This work was supported by research grants from the National Institutes of Health, USA, and the Foundation for Research Science and Technology, New Zealand. ",

year = "2000",

month = may,

day = "5",

doi = "10.1016/S0040-4020(00)00194-0",

language = "English (US)",

volume = "56",

pages = "3053--3062",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "19",

}

TY - JOUR

T1 - Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases

AU - Evans, Gary B.

AU - Furneaux, Richard H.

AU - Gainsford, Graeme J.

AU - Schramm, Vern L.

AU - Tyler, Peter C.

N1 - Funding Information: The authors thank Dr Herbert Wong for an excellent NMR service and Professor Robin Ferrier for assisting with the preparation of the manuscript. This work was supported by research grants from the National Institutes of Health, USA, and the Foundation for Research Science and Technology, New Zealand.

PY - 2000/5/5

Y1 - 2000/5/5

N2 - Syntheses of the 'Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5- deoxyfluoro- and 2-deoxy- analogues and others having modified bases. (C) 2000 Elsevier Science Ltd.

AB - Syntheses of the 'Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5- deoxyfluoro- and 2-deoxy- analogues and others having modified bases. (C) 2000 Elsevier Science Ltd.

KW - Carbohydrate mimetics

KW - Enzyme inhibitors

KW - Nucleosides

KW - Purines

UR - https://www.scopus.com/pages/publications/0034607824

UR - https://www.scopus.com/pages/publications/0034607824#tab=citedBy

U2 - 10.1016/S0040-4020(00)00194-0

DO - 10.1016/S0040-4020(00)00194-0

M3 - Article

AN - SCOPUS:0034607824

SN - 0040-4020

VL - 56

SP - 3053

EP - 3062

JO - Tetrahedron

JF - Tetrahedron

IS - 19

ER -

Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this