Abstract
Heart failure represents the leading cause of death, especially among the elderly. Despite the development of numerous therapeutic strategies, heart failure prevalence is still increasing. Ergo, exploring the molecular mechanisms underlying aging-related heart failure seems to be of particular relevance. Intriguingly, the fields of cardiovascular disease and aging, which have remained largely separate hitherto, seem to have a common point in the sympathetic nervous system. Indeed, mounting evidence indicates that adrenergic receptors are functionally involved in numerous processes underlying both aging and cardiovascular disease. This chapter will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiac aging.
| Original language | English (US) |
|---|---|
| Title of host publication | Pathophysiology and Pharmacotherapy of Cardiovascular Disease |
| Publisher | Springer International Publishing |
| Pages | 83-105 |
| Number of pages | 23 |
| ISBN (Electronic) | 9783319159614 |
| ISBN (Print) | 9783319159607 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Adrenergic receptors
- Aging
- Arrhythmias
- Cardiomyocytes
- Endothelium
- GRKs
- Heart failure
- Hypertension
- Sympathetic nervous system
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- General Medicine
Fingerprint
Dive into the research topics of 'Sympathetic nervous system signaling in heart failure and cardiac aging'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS