Surgical necrotizing enterocolitis and intraventricular hemorrhage in premature infants below 1000 g

Howard C. Jen, Jerome J. Graber, J. Laurance Hill, Samuel M. Alaish, Roger W. Voigt, Eric D. Strauch

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background/Purpose: Infants with very low birth weight are at increased risk for both intraventricular hemorrhage (IVH) and necrotizing enterocolitis (NEC). IVH often progresses in severity after initial diagnosis and causes severe neurological morbidity and mortality. The authors examined the role of NEC in the progression of IVH in these infants. Methods: The authors conducted a retrospective case-control study using data from the University of Maryland neonatal intensive care unit database between 1991 and 2003. From a cohort of 957 infants with very low birth weight, 53 pairs of infants labeled as IVH progression versus controls were selected and closely matched in respect to their gestational age and birth weight. Charts from these infants were reviewed to identify risk factors contributing to IVH progression. Results: Infants with IVH progression were significantly more likely to suffer from NEC (odds ratio, 3.6), whereas infants with surgical NEC showed a greater association with IVH progression (odds ratio, 5.33). Association with thrombocytopenia was also seen (odds ratio, 3.33). Sepsis showed trend toward significance (odds ratio, 1.9; P = .095) for progression of IVH. Conclusion: Surgical NEC showed the greatest risk for IVH progression. NEC and thrombocytopenia also appear to be risk factors for IVH progression.

Original languageEnglish (US)
Pages (from-to)1425-1430
Number of pages6
JournalJournal of Pediatric Surgery
Issue number8
StatePublished - Aug 2006
Externally publishedYes


  • Intraventricular hemorrhage
  • Necrotizing enterocolitis
  • Very low birth weight infants

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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