Supra-Plasma Expanders: The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions?

Amy G. Tsai, Beatriz Y.Salazar Vázquez, Axel Hofmann, Seetharama A. Acharya, Marcos Intaglietta

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Oxygen delivery capacity during profoundly anemic conditions depends on blood's oxygen-carrying capacity and cardiac output. Oxygen-carrying blood substitutes and blood transfusion augment oxygen-carrying capacity, but both have given rise to safety concerns, and their efficacy remains unresolved. Anemia decreases oxygen-carrying capacity and blood viscosity. Present studies show that correcting the decrease of blood viscosity by increasing plasma viscosity with newly developed plasma expanders significantly improves tissue perfusion. These new plasma expanders promote tissue perfusion, increasing oxygen delivery capacity without increasing blood oxygen-carrying capacity, thus treating the effects of anemia while avoiding the transfusion of blood.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalJournal of Infusion Nursing
Issue number3
StatePublished - Dec 1 2015


  • blood transfusion
  • hemorrhage
  • microcirculation
  • microvascular perfusion
  • oxygen delivery
  • oxygen transport
  • transfusion alternatives

ASJC Scopus subject areas

  • Nursing(all)


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