Supra-Plasma Expanders: The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions?

Amy G. Tsai; Beatriz Y.Salazar Vázquez; Axel Hofmann; Seetharama A. Acharya; Marcos Intaglietta

doi:10.1097/NAN.0000000000000103

Supra-Plasma Expanders: The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions?

Amy G. Tsai, Beatriz Y.Salazar Vázquez, Axel Hofmann, Seetharama A. Acharya, Marcos Intaglietta

Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Oxygen delivery capacity during profoundly anemic conditions depends on blood's oxygen-carrying capacity and cardiac output. Oxygen-carrying blood substitutes and blood transfusion augment oxygen-carrying capacity, but both have given rise to safety concerns, and their efficacy remains unresolved. Anemia decreases oxygen-carrying capacity and blood viscosity. Present studies show that correcting the decrease of blood viscosity by increasing plasma viscosity with newly developed plasma expanders significantly improves tissue perfusion. These new plasma expanders promote tissue perfusion, increasing oxygen delivery capacity without increasing blood oxygen-carrying capacity, thus treating the effects of anemia while avoiding the transfusion of blood.

Original language	English (US)
Pages (from-to)	217-222
Number of pages	6
Journal	Journal of Infusion Nursing
Volume	38
Issue number	3
DOIs	https://doi.org/10.1097/NAN.0000000000000103
State	Published - Dec 1 2015

Keywords

blood transfusion
hemorrhage
microcirculation
microvascular perfusion
oxygen delivery
oxygen transport
transfusion alternatives

ASJC Scopus subject areas

Nursing(all)

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10.1097/NAN.0000000000000103

Cite this

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title = "Supra-Plasma Expanders: The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions?",

abstract = "Oxygen delivery capacity during profoundly anemic conditions depends on blood's oxygen-carrying capacity and cardiac output. Oxygen-carrying blood substitutes and blood transfusion augment oxygen-carrying capacity, but both have given rise to safety concerns, and their efficacy remains unresolved. Anemia decreases oxygen-carrying capacity and blood viscosity. Present studies show that correcting the decrease of blood viscosity by increasing plasma viscosity with newly developed plasma expanders significantly improves tissue perfusion. These new plasma expanders promote tissue perfusion, increasing oxygen delivery capacity without increasing blood oxygen-carrying capacity, thus treating the effects of anemia while avoiding the transfusion of blood.",

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AU - Acharya, Seetharama A.

AU - Intaglietta, Marcos

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KW - microvascular perfusion

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Supra-Plasma Expanders: The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions?

Abstract

Keywords

ASJC Scopus subject areas

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