Suppressing malignant arrhythmias rapidly with oral amiodarone loading

S. G. Kim, Whee Choue Chung Whee Choue, M. M. Mannino, R. Chou, S. Roth, J. A. Roth, B. Desai, K. J. Ferrick, J. D. Fisher

Research output: Contribution to journalArticlepeer-review


Serial ambulatory electrocardiographic monitoring was used to study the time course of the effects of oral amiodarone during a loading period in 50 patients with sustained ventricular tachycardia or ventricular fibrillation. Rapid, dramatic decreases in episodes of ventricular premature complexes, couplets, and nonsustained ventricular tachycardia were noted within 72 hours. Subsequent decreases in spontaneous arrhythmias, although statistically significant, were less marked. When judged by suppression of spontaneous ventricular arrhythmias noted during Holter monitoring, oral amiodarone given in loading doses has a rapid onset of action.

Original languageEnglish (US)
Pages (from-to)22-24+29
JournalCardiology Board Review
Issue number11
StatePublished - 1993

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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