Original language | English (US) |
---|---|
Pages (from-to) | 627-628 |
Number of pages | 2 |
Journal | Nature Aging |
Volume | 3 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2023 |
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Aging
- Geriatrics and Gerontology
Access to Document
Other files and links
Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
In: Nature Aging, Vol. 3, No. 6, 06.2023, p. 627-628.
Research output: Contribution to journal › Letter › peer-review
}
TY - JOUR
T1 - SuperAger Initiative
T2 - unlocking the genetic potential of exceptional longevity
AU - Milman, Sofiya
AU - Barzilai, Nir
AU - Wilson, Kara A.
AU - Van der Willik, Odette
AU - Lederman, Stephanie
AU - Perls, Thomas
AU - Gao, Tina
AU - Leahy, Aoife Mc Govern
AU - Jain, Praduman
AU - Montgomery, Aisha
AU - Shuldiner, Alan R.
N1 - Funding Information: The SuperAger Initiative is a collaboration between academic, nonprofit and industry leaders, orchestrated by the American Federation for Aging Research with generous support from the James Fickel Family Foundation. The SuperAgers Family Study aims to assemble the largest cohort of super-agers to date and to mitigate the problem of insufficient statistical power for discovery of longevity-associated genetic variants. Over a three-year period, the study aims to enroll 10,000 individuals aged 95 and older with preserved cognitive capacity, along with their offspring and offspring-in-law. The offspring of parents with exceptional lifespan are enriched with longevity genetic variants and the children-in-law will serve as a comparison group without a genetic predisposition for longevity. Individuals from diverse ethnic and racial groups across the USA are encouraged to participate. The study recruitment campaign includes raising awareness about the study in geriatric communities through talks and printed materials, media placements and other outreach efforts at community and national levels. The cross-sectional study collects self-reported medical, family, lifestyle and daily activity information by questionnaire, as well as linkage with electronic health records using online digital technology developed in collaboration with Vibrent Health. The health information will be linked to whole-exome sequencing and genome-wide genotyping obtained from DNA collected by mail-in saliva kits. All research data and samples can be collected remotely, reducing participant burden and the cost of research; however, assistance from a study coordinator is available. Participants can opt in to being contacted in the future for additional research studies. Funding Information: This work is funded by a grant from the American Federation for Aging Research (S.M.) and the Fickel Family Charitable Fund (K.A.W., O.V.d.W. and S.L.). The authors also report receiving the following grant funding from the Glenn Foundation for Medical Research (N.B.) and the National Institutes of Health (NIH): R01AG061155 (S.M.), R56AG044829 (S.M.), P30AG038072 (N.B.), U24AG065204 (K.A.W., O.V.d.W. and S.L.), U24AG056053 (K.A.W., O.V.d.W. and S.L.), U24AG058556 (K.A.W., O.V.d.W. and S.L.), UH3AG064704 (T.P.), U24OD023163 (P.J. and A.M.), 3OT2OD030043 (P.J.), 75N91020C00038 (P.J.), HHSN261201700003C (P.J.) and UL1TR003098 (A.R.S.).
PY - 2023/6
Y1 - 2023/6
UR - http://www.scopus.com/inward/record.url?scp=85159696983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85159696983&partnerID=8YFLogxK
U2 - 10.1038/s43587-023-00429-7
DO - 10.1038/s43587-023-00429-7
M3 - Letter
AN - SCOPUS:85159696983
SN - 2662-8465
VL - 3
SP - 627
EP - 628
JO - Nature Aging
JF - Nature Aging
IS - 6
ER -