Sumatriptan relieves migrainelike headaches associated with carbon monoxide exposure

Richard B. Lipton, Cynthia Mazer, Lawrence C. Newman, Seymour Solomon

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


We report a 58-year-old woman with long-standing migraine who developed a pattern of weekend headaches which occurred only while staying at her Connecticut vacation home. The headaches promptly responded to sumatriptan. Investigation revealed a high carbon monoxide level In her home due to a defective furnace. Replacing the furnace eliminated the headaches. This case highlights the importance of searching for secondary causes of headache even in patients responsive to sumatriptan. It also suggests that carbon monoxide may trigger headaches mediated by trigeminovascular inflammation.

Original languageEnglish (US)
Pages (from-to)392-395
Number of pages4
Issue number6
StatePublished - Jun 1997


  • Carbon monoxide
  • Migraine
  • Sumatriptan

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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