Subclinical cardiovascular disease in HIV controller and long-term nonprogressor populations

R. M. Brusca; D. B. Hanna; N. I. Wada; J. N. Blankson; M. D. Witt; L. P. Jacobson; L. Kingsley; F. J. Palella; M. Budoff; T. T. Brown; K. Anastos; J. M. Lazar; W. J. Mack; P. Bacchetti; P. C. Tien; Y. Golzar; M. Plankey; E. Golub; R. C. Kaplan; W. S. Post

doi:10.1111/hiv.12820

Subclinical cardiovascular disease in HIV controller and long-term nonprogressor populations

R. M. Brusca, D. B. Hanna, N. I. Wada, J. N. Blankson, M. D. Witt, L. P. Jacobson, L. Kingsley, F. J. Palella, M. Budoff, T. T. Brown, K. Anastos, J. M. Lazar, W. J. Mack, P. Bacchetti, P. C. Tien, Y. Golzar, M. Plankey, E. Golub, R. C. Kaplan, W. S. Post

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Objectives: Elite controllers (ECs), viraemic controllers (VCs), and long-term nonprogressors (LTNPs) control HIV viral replication or maintain CD4 T-cell counts without antiretroviral therapy, but may have increased cardiovascular disease (CVD) risk compared to HIV-uninfected persons. We evaluated subclinical carotid and coronary atherosclerosis and inflammatory biomarker levels among HIV controllers, LTNPs and noncontrollers and HIV-uninfected individuals in the Multicenter AIDS Cohort Study (MACS) and the Women’s Interagency HIV Study (WIHS). Methods: We measured carotid plaque presence and common carotid artery intima-media thickness (IMT) in 1729 women and 1308 men, and the presence of coronary artery calcium and plaque in a subgroup of men. Associations between HIV control category and carotid and coronary plaque prevalences were assessed by multivariable regression analyses adjusting for demographics and CVD risk factors. Serum inflammatory biomarker concentrations [soluble CD163 (sCD163), soluble CD14 (sCD14), galectin-3 (Gal-3), galectin-3 binding protein (Gal-3BP) and interleukin (IL)-6] were measured and associations with HIV control category assessed. Results: We included 135 HIV controllers (30 ECs) and 135 LTNPs in the study. Carotid plaque prevalence and carotid IMT were similar in HIV controllers, LTNPs and HIV-uninfected individuals. HIV controllers and LTNPs had lower prevalences of carotid plaque compared to viraemic HIV-infected individuals. The prevalence of coronary atherosclerosis was similar in HIV controllers/LTNPs compared to HIV-uninfected and viraemic HIV-infected men. Controllers and LTNPs had higher concentrations of sCD163 and sCD14 compared to HIV-uninfected persons. Conclusions: Subclinical CVD was similar in HIV controllers, LTNPs and HIV-uninfected individuals despite elevated levels of some inflammatory biomarkers. Future studies of HIV controllers and LTNPs are needed to characterize the risk of CVD among HIV-infected persons.

Original language	English (US)
Pages (from-to)	217-227
Number of pages	11
Journal	HIV Medicine
Volume	21
Issue number	4
DOIs	https://doi.org/10.1111/hiv.12820
State	Published - Apr 1 2020

Keywords

AIDS
HIV
carotid atherosclerosis
coronary atherosclerosis
subclinical cardiovascular disease

ASJC Scopus subject areas

Health Policy
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/hiv.12820

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Brusca, R. M., Hanna, D. B., Wada, N. I., Blankson, J. N., Witt, M. D., Jacobson, L. P., Kingsley, L., Palella, F. J., Budoff, M., Brown, T. T., Anastos, K., Lazar, J. M., Mack, W. J., Bacchetti, P., Tien, P. C., Golzar, Y., Plankey, M., Golub, E., Kaplan, R. C., & Post, W. S. (2020). Subclinical cardiovascular disease in HIV controller and long-term nonprogressor populations. HIV Medicine, 21(4), 217-227. https://doi.org/10.1111/hiv.12820

Brusca, RM, Hanna, DB, Wada, NI, Blankson, JN, Witt, MD, Jacobson, LP, Kingsley, L, Palella, FJ, Budoff, M, Brown, TT, Anastos, K, Lazar, JM, Mack, WJ, Bacchetti, P, Tien, PC, Golzar, Y, Plankey, M, Golub, E, Kaplan, RC & Post, WS 2020, 'Subclinical cardiovascular disease in HIV controller and long-term nonprogressor populations', HIV Medicine, vol. 21, no. 4, pp. 217-227. https://doi.org/10.1111/hiv.12820

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title = "Subclinical cardiovascular disease in HIV controller and long-term nonprogressor populations",

abstract = "Objectives: Elite controllers (ECs), viraemic controllers (VCs), and long-term nonprogressors (LTNPs) control HIV viral replication or maintain CD4 T-cell counts without antiretroviral therapy, but may have increased cardiovascular disease (CVD) risk compared to HIV-uninfected persons. We evaluated subclinical carotid and coronary atherosclerosis and inflammatory biomarker levels among HIV controllers, LTNPs and noncontrollers and HIV-uninfected individuals in the Multicenter AIDS Cohort Study (MACS) and the Women{\textquoteright}s Interagency HIV Study (WIHS). Methods: We measured carotid plaque presence and common carotid artery intima-media thickness (IMT) in 1729 women and 1308 men, and the presence of coronary artery calcium and plaque in a subgroup of men. Associations between HIV control category and carotid and coronary plaque prevalences were assessed by multivariable regression analyses adjusting for demographics and CVD risk factors. Serum inflammatory biomarker concentrations [soluble CD163 (sCD163), soluble CD14 (sCD14), galectin-3 (Gal-3), galectin-3 binding protein (Gal-3BP) and interleukin (IL)-6] were measured and associations with HIV control category assessed. Results: We included 135 HIV controllers (30 ECs) and 135 LTNPs in the study. Carotid plaque prevalence and carotid IMT were similar in HIV controllers, LTNPs and HIV-uninfected individuals. HIV controllers and LTNPs had lower prevalences of carotid plaque compared to viraemic HIV-infected individuals. The prevalence of coronary atherosclerosis was similar in HIV controllers/LTNPs compared to HIV-uninfected and viraemic HIV-infected men. Controllers and LTNPs had higher concentrations of sCD163 and sCD14 compared to HIV-uninfected persons. Conclusions: Subclinical CVD was similar in HIV controllers, LTNPs and HIV-uninfected individuals despite elevated levels of some inflammatory biomarkers. Future studies of HIV controllers and LTNPs are needed to characterize the risk of CVD among HIV-infected persons.",

keywords = "AIDS, HIV, carotid atherosclerosis, coronary atherosclerosis, subclinical cardiovascular disease",

author = "Brusca, {R. M.} and Hanna, {D. B.} and Wada, {N. I.} and Blankson, {J. N.} and Witt, {M. D.} and Jacobson, {L. P.} and L. Kingsley and Palella, {F. J.} and M. Budoff and Brown, {T. T.} and K. Anastos and Lazar, {J. M.} and Mack, {W. J.} and P. Bacchetti and Tien, {P. C.} and Y. Golzar and M. Plankey and E. Golub and Kaplan, {R. C.} and Post, {W. S.}",

note = "Publisher Copyright: {\textcopyright} 2019 British HIV Association",

year = "2020",

month = apr,

day = "1",

doi = "10.1111/hiv.12820",

language = "English (US)",

volume = "21",

pages = "217--227",

journal = "HIV Medicine",

issn = "1464-2662",

publisher = "Wiley-Blackwell",

number = "4",

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TY - JOUR

T1 - Subclinical cardiovascular disease in HIV controller and long-term nonprogressor populations

AU - Brusca, R. M.

AU - Hanna, D. B.

AU - Wada, N. I.

AU - Blankson, J. N.

AU - Witt, M. D.

AU - Jacobson, L. P.

AU - Kingsley, L.

AU - Palella, F. J.

AU - Budoff, M.

AU - Brown, T. T.

AU - Anastos, K.

AU - Lazar, J. M.

AU - Mack, W. J.

AU - Bacchetti, P.

AU - Tien, P. C.

AU - Golzar, Y.

AU - Plankey, M.

AU - Golub, E.

AU - Kaplan, R. C.

AU - Post, W. S.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Objectives: Elite controllers (ECs), viraemic controllers (VCs), and long-term nonprogressors (LTNPs) control HIV viral replication or maintain CD4 T-cell counts without antiretroviral therapy, but may have increased cardiovascular disease (CVD) risk compared to HIV-uninfected persons. We evaluated subclinical carotid and coronary atherosclerosis and inflammatory biomarker levels among HIV controllers, LTNPs and noncontrollers and HIV-uninfected individuals in the Multicenter AIDS Cohort Study (MACS) and the Women’s Interagency HIV Study (WIHS). Methods: We measured carotid plaque presence and common carotid artery intima-media thickness (IMT) in 1729 women and 1308 men, and the presence of coronary artery calcium and plaque in a subgroup of men. Associations between HIV control category and carotid and coronary plaque prevalences were assessed by multivariable regression analyses adjusting for demographics and CVD risk factors. Serum inflammatory biomarker concentrations [soluble CD163 (sCD163), soluble CD14 (sCD14), galectin-3 (Gal-3), galectin-3 binding protein (Gal-3BP) and interleukin (IL)-6] were measured and associations with HIV control category assessed. Results: We included 135 HIV controllers (30 ECs) and 135 LTNPs in the study. Carotid plaque prevalence and carotid IMT were similar in HIV controllers, LTNPs and HIV-uninfected individuals. HIV controllers and LTNPs had lower prevalences of carotid plaque compared to viraemic HIV-infected individuals. The prevalence of coronary atherosclerosis was similar in HIV controllers/LTNPs compared to HIV-uninfected and viraemic HIV-infected men. Controllers and LTNPs had higher concentrations of sCD163 and sCD14 compared to HIV-uninfected persons. Conclusions: Subclinical CVD was similar in HIV controllers, LTNPs and HIV-uninfected individuals despite elevated levels of some inflammatory biomarkers. Future studies of HIV controllers and LTNPs are needed to characterize the risk of CVD among HIV-infected persons.

AB - Objectives: Elite controllers (ECs), viraemic controllers (VCs), and long-term nonprogressors (LTNPs) control HIV viral replication or maintain CD4 T-cell counts without antiretroviral therapy, but may have increased cardiovascular disease (CVD) risk compared to HIV-uninfected persons. We evaluated subclinical carotid and coronary atherosclerosis and inflammatory biomarker levels among HIV controllers, LTNPs and noncontrollers and HIV-uninfected individuals in the Multicenter AIDS Cohort Study (MACS) and the Women’s Interagency HIV Study (WIHS). Methods: We measured carotid plaque presence and common carotid artery intima-media thickness (IMT) in 1729 women and 1308 men, and the presence of coronary artery calcium and plaque in a subgroup of men. Associations between HIV control category and carotid and coronary plaque prevalences were assessed by multivariable regression analyses adjusting for demographics and CVD risk factors. Serum inflammatory biomarker concentrations [soluble CD163 (sCD163), soluble CD14 (sCD14), galectin-3 (Gal-3), galectin-3 binding protein (Gal-3BP) and interleukin (IL)-6] were measured and associations with HIV control category assessed. Results: We included 135 HIV controllers (30 ECs) and 135 LTNPs in the study. Carotid plaque prevalence and carotid IMT were similar in HIV controllers, LTNPs and HIV-uninfected individuals. HIV controllers and LTNPs had lower prevalences of carotid plaque compared to viraemic HIV-infected individuals. The prevalence of coronary atherosclerosis was similar in HIV controllers/LTNPs compared to HIV-uninfected and viraemic HIV-infected men. Controllers and LTNPs had higher concentrations of sCD163 and sCD14 compared to HIV-uninfected persons. Conclusions: Subclinical CVD was similar in HIV controllers, LTNPs and HIV-uninfected individuals despite elevated levels of some inflammatory biomarkers. Future studies of HIV controllers and LTNPs are needed to characterize the risk of CVD among HIV-infected persons.

KW - AIDS

KW - HIV

KW - carotid atherosclerosis

KW - coronary atherosclerosis

KW - subclinical cardiovascular disease

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DO - 10.1111/hiv.12820

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JO - HIV Medicine

JF - HIV Medicine

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ER -

Subclinical cardiovascular disease in HIV controller and long-term nonprogressor populations

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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