Study on the animal model for severe acute respiratory syndrome

Bo Hua Liu, Dong Lai Wu, Da Wei Zhan, E. De Qin, Qing Yu Zhu, Cui E. Wang, Qing Wen Meng, Wen Ming Peng, Xun Nan Yin, Yin Hui Yang, Yun Tao Guan, Wei Guo Han, Chang Wen Li, Yong Gang Liu, Mou Ping Wang, Quan Gui Liu, Hui Ying Shi, Zhi Fen Ding

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


To screen small animals susceptible to SARS-CoV, five species of animals, including guinea pig, hamster, albino hamster, chicken and rat, were experimentally infected with SARS-CoV strain BJ-01 by different routes. On the basis of this, further cynomolgus and rhesus macaques were selected and experimentally inoculated SARS-CoV, the quality they serve as animal model for SARS was evaluated. The results showed that, all five species of small animals chosed were not susceptible to SARS-CoV, no characterized changes in clinical sign and histopathology were observed after infection, but from the lung samples of large rat and pig guinea, the genomic RNA of SARS-CoV could be detected by RT-PCR at day 14 post infection, this suggested that SARS-CoV could replicate in these animals. After inoculated with SARS-CoV, all inoculated cynomolgus and rhesus macaques had developed interstitial pneumonia of differing severity. These changes on histopathology were similar to that seen in SARS patients, but the pathological lesions were less severe than that of human. Except interstitial pneumonia, no other characterized pathological changes were observed. This suggested cynomolgus and rhesus macaques were not the ideal animal model for SARS in fact, but they could serve as animal model for SARS when a more ideal animal model is absent.

Original languageEnglish (US)
Pages (from-to)711-716
Number of pages6
JournalWei sheng wu xue bao = Acta microbiologica Sinica
Issue number6
StatePublished - Dec 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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