TY - JOUR
T1 - Studies on the nerve growth factor(NGF) from snake venom molecular heterogeneity
AU - Angeletti, Ruth Hogue
N1 - Funding Information:
The. autlior wishes to ,‘thank Prof. G: R. MARINI-B,ETTbLo : and“Dr. cRITA LEVI-MONTALCINI for advice and ,encouragement; The technical’ assistance of: (2 COZZARI and A‘ .’~‘ DI~LuzIo, is gratefully acknowledged. The work v+as supported ,by t‘he Mercki Sharp and Dohme Co. ,:_: :,: ,..
PY - 1968
Y1 - 1968
N2 - The nerve growth factor from the venoms of Crotalus adamanteus and Bothrops jararaca was analyzed by chromatography and gel filtration. The data obtained suggest that purified nerve growth factor aggregates and dissociates to form active molecules of various molecular weights. Evidence was found for the existence of an active nerve growth factor, possibly a fragment or a subunit, having a molecular weight of less than 5,000.
AB - The nerve growth factor from the venoms of Crotalus adamanteus and Bothrops jararaca was analyzed by chromatography and gel filtration. The data obtained suggest that purified nerve growth factor aggregates and dissociates to form active molecules of various molecular weights. Evidence was found for the existence of an active nerve growth factor, possibly a fragment or a subunit, having a molecular weight of less than 5,000.
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U2 - 10.1016/s0021-9673(01)99071-5
DO - 10.1016/s0021-9673(01)99071-5
M3 - Article
C2 - 5683269
AN - SCOPUS:0014428811
SN - 0021-9673
VL - 37
SP - 62
EP - 69
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - C
ER -