Structure of the sodium channel pore revealed by serial cysteine mutagenesis

M. T. Pérez-García, N. Chiamvimonvat, E. Marban, G. F. Tomaselli

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


The pores of voltage-gated cation channels are formed by four intramembrane segments that impart selectivity and conductance. Remarkably little is known about the higher order structure of these critical pure- lining or P segments. Serial cysteine mutagenesis reveals a pattern of side- chain accessibility that contradicts currently favored structural models based on α-helices or β-strands. Like the active sites of many enzymes of known structure, the sodium channel pore consists of irregular loop regions.

Original languageEnglish (US)
Pages (from-to)300-304
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number1
StatePublished - Jan 9 1996
Externally publishedYes

ASJC Scopus subject areas

  • General


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