Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with a Short Positive-Sense Gene-End RNA

Yunrong Gao; Dongdong Cao; Shristi Pawnikar; Karen P. John; Hyunjun Max Ahn; Shaylan Hill; Ju Mi Ha; Priyal Parikh; Claire Ogilvie; Anshuman Swain; Amy Yang; Amber Bell; Angela Salazar; Yinglong Miao; Bo Liang

doi:10.1016/j.str.2020.07.001

Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with a Short Positive-Sense Gene-End RNA

Yunrong Gao
, Dongdong Cao
, Shristi Pawnikar
, Karen P. John
, Hyunjun Max Ahn
, Shaylan Hill
, Ju Mi Ha
, Priyal Parikh
, Claire Ogilvie
, Anshuman Swain
, Amy Yang
, Amber Bell
, Angela Salazar
, Yinglong Miao
, Bo Liang

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Gao et al. determined a 2.7-Å resolution crystal structure of human respiratory syncytial virus (HRSV) M2-1 protein in complex with a short positive-sense gene-end RNA. Gaussian accelerated molecular dynamics (GaMD) simulations captured spontaneous binding of RNA to M2-1. The results provided a structural basis for RNA recognition by M2-1.

Original language	English (US)
Pages (from-to)	979-990.e4
Journal	Structure
Volume	28
Issue number	9
DOIs	https://doi.org/10.1016/j.str.2020.07.001
State	Published - Sep 1 2020
Externally published	Yes

Keywords

Gaussian accelerated molecular dynamics
M2-1
RNA
crystal structure
human respiratory syncytial virus
microscale thermophoresis assay
simulations
structural basis

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/j.str.2020.07.001

Cite this

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title = "Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with a Short Positive-Sense Gene-End RNA",

abstract = "Gao et al. determined a 2.7-{\AA} resolution crystal structure of human respiratory syncytial virus (HRSV) M2-1 protein in complex with a short positive-sense gene-end RNA. Gaussian accelerated molecular dynamics (GaMD) simulations captured spontaneous binding of RNA to M2-1. The results provided a structural basis for RNA recognition by M2-1.",

keywords = "Gaussian accelerated molecular dynamics, M2-1, RNA, crystal structure, human respiratory syncytial virus, microscale thermophoresis assay, simulations, structural basis",

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doi = "10.1016/j.str.2020.07.001",

language = "English (US)",

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AU - Gao, Yunrong

AU - Cao, Dongdong

AU - Pawnikar, Shristi

AU - John, Karen P.

AU - Ahn, Hyunjun Max

AU - Hill, Shaylan

AU - Ha, Ju Mi

AU - Parikh, Priyal

AU - Ogilvie, Claire

AU - Swain, Anshuman

AU - Yang, Amy

AU - Bell, Amber

AU - Salazar, Angela

AU - Miao, Yinglong

AU - Liang, Bo

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Gao et al. determined a 2.7-Å resolution crystal structure of human respiratory syncytial virus (HRSV) M2-1 protein in complex with a short positive-sense gene-end RNA. Gaussian accelerated molecular dynamics (GaMD) simulations captured spontaneous binding of RNA to M2-1. The results provided a structural basis for RNA recognition by M2-1.

AB - Gao et al. determined a 2.7-Å resolution crystal structure of human respiratory syncytial virus (HRSV) M2-1 protein in complex with a short positive-sense gene-end RNA. Gaussian accelerated molecular dynamics (GaMD) simulations captured spontaneous binding of RNA to M2-1. The results provided a structural basis for RNA recognition by M2-1.

KW - Gaussian accelerated molecular dynamics

KW - M2-1

KW - RNA

KW - crystal structure

KW - human respiratory syncytial virus

KW - microscale thermophoresis assay

KW - simulations

KW - structural basis

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DO - 10.1016/j.str.2020.07.001

M3 - Article

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JF - Structure

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ER -

Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with a Short Positive-Sense Gene-End RNA

Abstract

Keywords

ASJC Scopus subject areas

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