Structure and function of mammalian cilia

Peter Satir; Søren T. Christensen

doi:10.1007/s00418-008-0416-9

Structure and function of mammalian cilia

Peter Satir, Søren T. Christensen

Research output: Contribution to journal › Review article › peer-review

153 Scopus citations

Abstract

In the past half century, beginning with electron microscopic studies of 9 + 2 motile and 9 + 0 primary cilia, novel insights have been obtained regarding the structure and function of mammalian cilia. All cilia can now be viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation. This view has had unanticipated consequences for our understanding of developmental processes and human disease.

Original language	English (US)
Pages (from-to)	687-693
Number of pages	7
Journal	Histochemistry and Cell Biology
Volume	129
Issue number	6
DOIs	https://doi.org/10.1007/s00418-008-0416-9
State	Published - Jun 2008
Externally published	Yes

Keywords

Ciliopathies
Motile cilia
Motility
Primary cilia
Sensory organelles
Signaling

ASJC Scopus subject areas

Histology
Molecular Biology
Medical Laboratory Technology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00418-008-0416-9

Cite this

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title = "Structure and function of mammalian cilia",

abstract = "In the past half century, beginning with electron microscopic studies of 9 + 2 motile and 9 + 0 primary cilia, novel insights have been obtained regarding the structure and function of mammalian cilia. All cilia can now be viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation. This view has had unanticipated consequences for our understanding of developmental processes and human disease.",

keywords = "Ciliopathies, Motile cilia, Motility, Primary cilia, Sensory organelles, Signaling",

author = "Peter Satir and Christensen, {S{\o}ren T.}",

note = "Funding Information: Acknowledgments We thank Raviraja Seetharam for helpful assistance. This work was supported in part by grants from the NIH to P.S. and from the Lundbeck Foundation (grant no. R9-A969) and The Danish Natural Science Research Council (grant no. 272-07-0530) to STC.",

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doi = "10.1007/s00418-008-0416-9",

language = "English (US)",

volume = "129",

pages = "687--693",

journal = "Histochemistry and Cell Biology",

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publisher = "Springer Verlag",

number = "6",

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T1 - Structure and function of mammalian cilia

AU - Satir, Peter

AU - Christensen, Søren T.

N1 - Funding Information: Acknowledgments We thank Raviraja Seetharam for helpful assistance. This work was supported in part by grants from the NIH to P.S. and from the Lundbeck Foundation (grant no. R9-A969) and The Danish Natural Science Research Council (grant no. 272-07-0530) to STC.

PY - 2008/6

Y1 - 2008/6

N2 - In the past half century, beginning with electron microscopic studies of 9 + 2 motile and 9 + 0 primary cilia, novel insights have been obtained regarding the structure and function of mammalian cilia. All cilia can now be viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation. This view has had unanticipated consequences for our understanding of developmental processes and human disease.

AB - In the past half century, beginning with electron microscopic studies of 9 + 2 motile and 9 + 0 primary cilia, novel insights have been obtained regarding the structure and function of mammalian cilia. All cilia can now be viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation. This view has had unanticipated consequences for our understanding of developmental processes and human disease.

KW - Ciliopathies

KW - Motile cilia

KW - Motility

KW - Primary cilia

KW - Sensory organelles

KW - Signaling

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U2 - 10.1007/s00418-008-0416-9

DO - 10.1007/s00418-008-0416-9

M3 - Review article

C2 - 18365235

AN - SCOPUS:44149123547

SN - 0948-6143

VL - 129

SP - 687

EP - 693

JO - Histochemistry and Cell Biology

JF - Histochemistry and Cell Biology

IS - 6

ER -

Structure and function of mammalian cilia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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