TY - JOUR
T1 - Stimulation of immature male rat liver growth by phenobarbital and 3-methylcholanthrene
AU - Augenlicht, Leonard H.
AU - Argyris, Thomas S.
N1 - Funding Information:
1 This work was supported by NSF Grant GB-12554 to Thomas S. Argyris and an NSF predoctoral fellowship to Leonard H. Augenlicht. This work was presented in preliminary form at the FASEB meetings (Fed. Proc. 31, 611 (1972). 2Present address: Memorial Sloan-Kettering Cancer Center, New York, New York 10021. s Present address: Department of Pathology, Upstate Medical Center, SUNY, Syracuse, New York 13210.
PY - 1975/2
Y1 - 1975/2
N2 - Daily injections of 100 mg phenobarbital/kg body wt stimulate substantial increases in liver growth. However, after 5 days of treatment there is no further growth in response to phenobarbital. At this time, the liver still grows after a single injection of 20 mg of 3-methylcholanthrene/kg body wt. It is concluded that the two drugs stimulate liver growth by different mechanisms, as they do liver drug metabolizing enzyme activity. In addition, we have shown that 100 mg phenobarbital/kg body wt in the immature male rat stimulates liver growth by both hepatocyte hypertrophy and hyperplasia, while 20 mg 3-methylcholanthrene/kg body wt with or without phenobarbital pretreatment stimulates only cell hypertrophy. Neither drug significantly affects mitotic activity in littoral or bile duct cells.
AB - Daily injections of 100 mg phenobarbital/kg body wt stimulate substantial increases in liver growth. However, after 5 days of treatment there is no further growth in response to phenobarbital. At this time, the liver still grows after a single injection of 20 mg of 3-methylcholanthrene/kg body wt. It is concluded that the two drugs stimulate liver growth by different mechanisms, as they do liver drug metabolizing enzyme activity. In addition, we have shown that 100 mg phenobarbital/kg body wt in the immature male rat stimulates liver growth by both hepatocyte hypertrophy and hyperplasia, while 20 mg 3-methylcholanthrene/kg body wt with or without phenobarbital pretreatment stimulates only cell hypertrophy. Neither drug significantly affects mitotic activity in littoral or bile duct cells.
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U2 - 10.1016/0014-4800(75)90045-3
DO - 10.1016/0014-4800(75)90045-3
M3 - Article
C2 - 1116562
AN - SCOPUS:0016440478
SN - 0014-4800
VL - 22
SP - 1
EP - 10
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
IS - 1
ER -