Status epilepticus

Syndi Seinfeld, Howard P. Goodkin, Shlomo Shinnar

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Although the majority of seizures are brief and cause no long-term consequences, a subset is sufficiently prolonged that long-term consequences can result. These very prolonged seizures are termed “status epilepticus” (SE) and are considered a neurological emergency. The clinical presentation of SE can be diverse. SE can occur at any age but most commonlyoccurs in the very young and the very old. There are numerous studies on SE in animals in which the pathophysiology, medication responses, and pathology can be rigorously studied in a controlled fashion. Human data are consistent with the animal data. In particular, febrile status epilepticus (FSE), a form of SE common in young children, is associated with injury to the hippocampus and subsequent temporal lobe epilepsy (TLE) in both animals and humans.

Original languageEnglish (US)
Article numbera022830
JournalCold Spring Harbor Perspectives in Medicine
Issue number3
StatePublished - Mar 2016

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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