Specific-nuclear triiodothyronine binding sites in rat liver and kidney

J. H. Oppenheimer; D. Koerner; H. L. Schwartz; M. I. Surks

doi:10.1210/jcem-35-2-330

Specific-nuclear triiodothyronine binding sites in rat liver and kidney

J. H. Oppenheimer, D. Koerner, H. L. Schwartz, M. I. Surks

Medicine

Research output: Contribution to journal › Article › peer-review

241 Scopus citations

Abstract

Injection of increasing quantities of L-triiodothyronine (T₃) resulted in a progressive decrease in the proportion of T₃ bound to the nuclear fraction of rat liver and kidney cells. A similar dose-response relationship could not be demonstrated for other ultracentrifugal fractions. Only a modest reduction in nuclear binding of thyroxine was observed after injection of large amounts of this iodothyronine. The results indicate the presence of relatively specific binding sites for T₃ in the nuclei of rat liver and kidney.

Original language	English (US)
Pages (from-to)	330-333
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	35
Issue number	2
DOIs	https://doi.org/10.1210/jcem-35-2-330
State	Published - Jan 1 1972

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/jcem-35-2-330

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AU - Schwartz, H. L.

AU - Surks, M. I.

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N2 - Injection of increasing quantities of L-triiodothyronine (T3) resulted in a progressive decrease in the proportion of T3 bound to the nuclear fraction of rat liver and kidney cells. A similar dose-response relationship could not be demonstrated for other ultracentrifugal fractions. Only a modest reduction in nuclear binding of thyroxine was observed after injection of large amounts of this iodothyronine. The results indicate the presence of relatively specific binding sites for T3 in the nuclei of rat liver and kidney.

AB - Injection of increasing quantities of L-triiodothyronine (T3) resulted in a progressive decrease in the proportion of T3 bound to the nuclear fraction of rat liver and kidney cells. A similar dose-response relationship could not be demonstrated for other ultracentrifugal fractions. Only a modest reduction in nuclear binding of thyroxine was observed after injection of large amounts of this iodothyronine. The results indicate the presence of relatively specific binding sites for T3 in the nuclei of rat liver and kidney.

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Specific-nuclear triiodothyronine binding sites in rat liver and kidney

Abstract

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