Spatiotemporal Insights Into RNA–Organelle Interactions in Neurons

Shivani C. Kharod, Dong Woo Hwang, Sulagna Das, Young J. Yoon

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Neurons exhibit spatial compartmentalization of gene expression where localization of messenger RNAs (mRNAs) to distal processes allows for site-specific distribution of proteins through local translation. Recently, there have been reports of coordination between mRNA transport with vesicular and organellar trafficking. In this review, we will highlight the latest literature on axonal and dendritic local protein synthesis with links to mRNA–organelle cotransport followed by emerging technologies necessary to study these phenomena. Recent high-resolution imaging studies have led to insights into the dynamics of RNA–organelle interactions, and we can now peer into these intricate interactions within subcellular compartments of neurons.

Original languageEnglish (US)
Article number663367
JournalFrontiers in Cell and Developmental Biology
StatePublished - Jun 10 2021


  • high-resolution imaging
  • mRNA translation
  • mRNA transport
  • neurons
  • organellar trafficking
  • single molecule imaging
  • vesicular trafficking

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


Dive into the research topics of 'Spatiotemporal Insights Into RNA–Organelle Interactions in Neurons'. Together they form a unique fingerprint.

Cite this