Spatial compartmentalization in the regulation of glucose metabolism by insulin

Matthew J. Brady, Jeffrey E. Pessin, Alan R. Saltiel

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Despite intense investigation, major gaps remain in our understanding of the cellular mechanisms that underlie the actions of insulin, as well as the regulation of the enzymes and transport proteins crucial to the orderly control of glucose metabolism. In recent years, the compartmentalization of signaling molecules and metabolic enzymes has been suggested to play an important role in ensuring metabolic balance. We will discuss examples of recent findings, suggesting that spatial compartmentalization and protein translocation might be the keys to understanding the specificity of insulin in the regulation of glucose metabolism.

Original languageEnglish (US)
Pages (from-to)408-413
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number10
StatePublished - Dec 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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