TY - JOUR
T1 - SOX factors as cell-state regulators in the mammary gland and breast cancer
AU - Liu, Yu
AU - Guo, Wenjun
N1 - Funding Information:
Work in the laboratory of W.G. was supported by grants from DOD BCRP ( BC151542 , BC161696P1 , BC171724 , and BC190403P1 ), NYSTEM ( C029571 and C34876GG ) and NIH/NCI ( 1R01CA212424 ). Y.L. was supported by the NYSTEM Training Grant ( C34874GG ). W.G. is a V Scholar of the V Foundation for Cancer Research and supported by the Mary Kay Foundation .
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/6
Y1 - 2021/6
N2 - Emerging evidence has shown that several SOX family transcription factors are key regulators of stem/progenitor cell fates in the mammary gland. These cell-fate regulators are often upregulated in breast cancer and contribute to tumor initiation and progression. They induce lineage plasticity and the epithelial-mesenchymal transition, which promotes tumor invasion, metastasis, and therapeutic resistance. SOX factors act through modulating multiple oncogenic signaling pathways in breast cancer. In addition to the cell-autonomous functions, new evidence suggests they can shape the tumor immune microenvironment. Here, we will review the molecular and functional evidence linking SOX factors with mammary gland development and discuss how these cell-fate regulators are co-opted in breast cancer.
AB - Emerging evidence has shown that several SOX family transcription factors are key regulators of stem/progenitor cell fates in the mammary gland. These cell-fate regulators are often upregulated in breast cancer and contribute to tumor initiation and progression. They induce lineage plasticity and the epithelial-mesenchymal transition, which promotes tumor invasion, metastasis, and therapeutic resistance. SOX factors act through modulating multiple oncogenic signaling pathways in breast cancer. In addition to the cell-autonomous functions, new evidence suggests they can shape the tumor immune microenvironment. Here, we will review the molecular and functional evidence linking SOX factors with mammary gland development and discuss how these cell-fate regulators are co-opted in breast cancer.
KW - Breast cancer
KW - Epithelial-mesenchymal transition
KW - Lineage plasticity
KW - Mammary gland development
KW - SOX transcription factors
KW - Tumor immune microenvironment
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U2 - 10.1016/j.semcdb.2021.01.002
DO - 10.1016/j.semcdb.2021.01.002
M3 - Review article
C2 - 33583737
AN - SCOPUS:85100613250
SN - 1084-9521
VL - 114
SP - 126
EP - 133
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -
