SOX factors as cell-state regulators in the mammary gland and breast cancer

Yu Liu; Wenjun Guo

doi:10.1016/j.semcdb.2021.01.002

SOX factors as cell-state regulators in the mammary gland and breast cancer

Yu Liu, Wenjun Guo

Cell Biology

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Emerging evidence has shown that several SOX family transcription factors are key regulators of stem/progenitor cell fates in the mammary gland. These cell-fate regulators are often upregulated in breast cancer and contribute to tumor initiation and progression. They induce lineage plasticity and the epithelial-mesenchymal transition, which promotes tumor invasion, metastasis, and therapeutic resistance. SOX factors act through modulating multiple oncogenic signaling pathways in breast cancer. In addition to the cell-autonomous functions, new evidence suggests they can shape the tumor immune microenvironment. Here, we will review the molecular and functional evidence linking SOX factors with mammary gland development and discuss how these cell-fate regulators are co-opted in breast cancer.

Original language	English (US)
Pages (from-to)	126-133
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	114
DOIs	https://doi.org/10.1016/j.semcdb.2021.01.002
State	Published - Jun 2021

Keywords

Breast cancer
Epithelial-mesenchymal transition
Lineage plasticity
Mammary gland development
SOX transcription factors
Tumor immune microenvironment

ASJC Scopus subject areas

Developmental Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semcdb.2021.01.002

Cite this

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title = "SOX factors as cell-state regulators in the mammary gland and breast cancer",

abstract = "Emerging evidence has shown that several SOX family transcription factors are key regulators of stem/progenitor cell fates in the mammary gland. These cell-fate regulators are often upregulated in breast cancer and contribute to tumor initiation and progression. They induce lineage plasticity and the epithelial-mesenchymal transition, which promotes tumor invasion, metastasis, and therapeutic resistance. SOX factors act through modulating multiple oncogenic signaling pathways in breast cancer. In addition to the cell-autonomous functions, new evidence suggests they can shape the tumor immune microenvironment. Here, we will review the molecular and functional evidence linking SOX factors with mammary gland development and discuss how these cell-fate regulators are co-opted in breast cancer.",

keywords = "Breast cancer, Epithelial-mesenchymal transition, Lineage plasticity, Mammary gland development, SOX transcription factors, Tumor immune microenvironment",

author = "Yu Liu and Wenjun Guo",

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year = "2021",

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doi = "10.1016/j.semcdb.2021.01.002",

language = "English (US)",

volume = "114",

pages = "126--133",

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AU - Liu, Yu

AU - Guo, Wenjun

PY - 2021/6

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N2 - Emerging evidence has shown that several SOX family transcription factors are key regulators of stem/progenitor cell fates in the mammary gland. These cell-fate regulators are often upregulated in breast cancer and contribute to tumor initiation and progression. They induce lineage plasticity and the epithelial-mesenchymal transition, which promotes tumor invasion, metastasis, and therapeutic resistance. SOX factors act through modulating multiple oncogenic signaling pathways in breast cancer. In addition to the cell-autonomous functions, new evidence suggests they can shape the tumor immune microenvironment. Here, we will review the molecular and functional evidence linking SOX factors with mammary gland development and discuss how these cell-fate regulators are co-opted in breast cancer.

AB - Emerging evidence has shown that several SOX family transcription factors are key regulators of stem/progenitor cell fates in the mammary gland. These cell-fate regulators are often upregulated in breast cancer and contribute to tumor initiation and progression. They induce lineage plasticity and the epithelial-mesenchymal transition, which promotes tumor invasion, metastasis, and therapeutic resistance. SOX factors act through modulating multiple oncogenic signaling pathways in breast cancer. In addition to the cell-autonomous functions, new evidence suggests they can shape the tumor immune microenvironment. Here, we will review the molecular and functional evidence linking SOX factors with mammary gland development and discuss how these cell-fate regulators are co-opted in breast cancer.

KW - Breast cancer

KW - Epithelial-mesenchymal transition

KW - Lineage plasticity

KW - Mammary gland development

KW - SOX transcription factors

KW - Tumor immune microenvironment

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U2 - 10.1016/j.semcdb.2021.01.002

DO - 10.1016/j.semcdb.2021.01.002

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JF - Seminars in Cell and Developmental Biology

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SOX factors as cell-state regulators in the mammary gland and breast cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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