Solvent-controlled asymmetric strecker reaction: Stereoselective synthesis of α-trifluoromethylated α-amino acids

Hua Wang; Xiaoming Zhao; Youhua Li; Long Lu

doi:10.1021/ol0601186

Solvent-controlled asymmetric strecker reaction: Stereoselective synthesis of α-trifluoromethylated α-amino acids

Hua Wang
, Xiaoming Zhao
, Youhua Li
, Long Lu

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Stereoselective approaches to α-trifluoromethylated α-amino acids (α-Tim AAs) have been developed. The stereoconfigurations of the resulting α-Tfm AA precursors were well controlled by using different solvents. The optically active (S)-2-amino-2-phenyl-1,1,1-trifluoropropanoic acid was synthesized by this method.

Original language	English (US)
Pages (from-to)	1379-1381
Number of pages	3
Journal	Organic Letters
Volume	8
Issue number	7
DOIs	https://doi.org/10.1021/ol0601186
State	Published - Mar 30 2006
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0601186

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title = "Solvent-controlled asymmetric strecker reaction: Stereoselective synthesis of α-trifluoromethylated α-amino acids",

abstract = "Stereoselective approaches to α-trifluoromethylated α-amino acids (α-Tim AAs) have been developed. The stereoconfigurations of the resulting α-Tfm AA precursors were well controlled by using different solvents. The optically active (S)-2-amino-2-phenyl-1,1,1-trifluoropropanoic acid was synthesized by this method.",

author = "Hua Wang and Xiaoming Zhao and Youhua Li and Long Lu",

year = "2006",

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doi = "10.1021/ol0601186",

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T2 - Stereoselective synthesis of α-trifluoromethylated α-amino acids

AU - Wang, Hua

AU - Zhao, Xiaoming

AU - Li, Youhua

AU - Lu, Long

PY - 2006/3/30

Y1 - 2006/3/30

N2 - Stereoselective approaches to α-trifluoromethylated α-amino acids (α-Tim AAs) have been developed. The stereoconfigurations of the resulting α-Tfm AA precursors were well controlled by using different solvents. The optically active (S)-2-amino-2-phenyl-1,1,1-trifluoropropanoic acid was synthesized by this method.

AB - Stereoselective approaches to α-trifluoromethylated α-amino acids (α-Tim AAs) have been developed. The stereoconfigurations of the resulting α-Tfm AA precursors were well controlled by using different solvents. The optically active (S)-2-amino-2-phenyl-1,1,1-trifluoropropanoic acid was synthesized by this method.

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UR - https://www.scopus.com/pages/publications/33645927022#tab=citedBy

U2 - 10.1021/ol0601186

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JO - Organic Letters

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Solvent-controlled asymmetric strecker reaction: Stereoselective synthesis of α-trifluoromethylated α-amino acids

Abstract

ASJC Scopus subject areas

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