Soft-tissue sarcomas

Santiago A. Lozano-Calderon; Mitchell S. Fourman; Dipak B. Ramkumar

doi:10.1007/978-3-031-30518-4_184

Soft-tissue sarcomas

Santiago A. Lozano-Calderon
, Mitchell S. Fourman
, Dipak B. Ramkumar

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Soft-tissue sarcomas are rare entities with myriad presentations, characteristics, and prognoses. The diagnosis and management of soft-tissue sarcomas differ by their tissue of origin and their sensitivity to radiation and systemic therapies. While many soft-tissue sarcomas, such as myxofibrosarcoma and liposarcoma, can be managed with preoperative radiotherapy followed by wide excision, entities such as Ewing's sarcoma can be treated with chemotherapy and radiation alone. This chapter summarizes the differentiating pathologic and radiographic characteristics between types of soft-tissue sarcomas as well as literature-supported diagnostic and treatment strategies. The utility of chemotherapy and immunotherapy in the treatment of soft-tissue sarcoma will be addressed. Finally, currently available prognostic indices and their utility will be discussed.

Original language	English (US)
Title of host publication	Orthopaedics and Trauma
Subtitle of host publication	Current Concepts and Best Practices
Publisher	Springer International Publishing
Pages	2133-2162
Number of pages	30
ISBN (Electronic)	9783031305184
ISBN (Print)	9783031305177
DOIs	https://doi.org/10.1007/978-3-031-30518-4_184
State	Published - Jun 5 2024
Externally published	Yes

Keywords

Chemotherapy
Histology
Outcomes
Soft-tissue sarcoma
Tumor diagnosis

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-031-30518-4_184

Cite this

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abstract = "Soft-tissue sarcomas are rare entities with myriad presentations, characteristics, and prognoses. The diagnosis and management of soft-tissue sarcomas differ by their tissue of origin and their sensitivity to radiation and systemic therapies. While many soft-tissue sarcomas, such as myxofibrosarcoma and liposarcoma, can be managed with preoperative radiotherapy followed by wide excision, entities such as Ewing's sarcoma can be treated with chemotherapy and radiation alone. This chapter summarizes the differentiating pathologic and radiographic characteristics between types of soft-tissue sarcomas as well as literature-supported diagnostic and treatment strategies. The utility of chemotherapy and immunotherapy in the treatment of soft-tissue sarcoma will be addressed. Finally, currently available prognostic indices and their utility will be discussed.",

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AU - Lozano-Calderon, Santiago A.

AU - Fourman, Mitchell S.

AU - Ramkumar, Dipak B.

PY - 2024/6/5

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N2 - Soft-tissue sarcomas are rare entities with myriad presentations, characteristics, and prognoses. The diagnosis and management of soft-tissue sarcomas differ by their tissue of origin and their sensitivity to radiation and systemic therapies. While many soft-tissue sarcomas, such as myxofibrosarcoma and liposarcoma, can be managed with preoperative radiotherapy followed by wide excision, entities such as Ewing's sarcoma can be treated with chemotherapy and radiation alone. This chapter summarizes the differentiating pathologic and radiographic characteristics between types of soft-tissue sarcomas as well as literature-supported diagnostic and treatment strategies. The utility of chemotherapy and immunotherapy in the treatment of soft-tissue sarcoma will be addressed. Finally, currently available prognostic indices and their utility will be discussed.

AB - Soft-tissue sarcomas are rare entities with myriad presentations, characteristics, and prognoses. The diagnosis and management of soft-tissue sarcomas differ by their tissue of origin and their sensitivity to radiation and systemic therapies. While many soft-tissue sarcomas, such as myxofibrosarcoma and liposarcoma, can be managed with preoperative radiotherapy followed by wide excision, entities such as Ewing's sarcoma can be treated with chemotherapy and radiation alone. This chapter summarizes the differentiating pathologic and radiographic characteristics between types of soft-tissue sarcomas as well as literature-supported diagnostic and treatment strategies. The utility of chemotherapy and immunotherapy in the treatment of soft-tissue sarcoma will be addressed. Finally, currently available prognostic indices and their utility will be discussed.

KW - Chemotherapy

KW - Histology

KW - Outcomes

KW - Soft-tissue sarcoma

KW - Tumor diagnosis

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M3 - Chapter

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EP - 2162

BT - Orthopaedics and Trauma

PB - Springer International Publishing

ER -

Soft-tissue sarcomas

Abstract

Keywords

ASJC Scopus subject areas

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