Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits

Thomas Blank; Ingrid Nijholt; Min Jeong Kye; Jelena Radulovic; Joachim Spiess

doi:10.1038/nn1101

Small-conductance, Ca²⁺-activated K⁺ channel SK3 generates age-related memory and LTP deficits

Thomas Blank, Ingrid Nijholt, Min Jeong Kye, Jelena Radulovic, Joachim Spiess

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus. Here we show that elevated expression of small-conductance Ca ²⁺-activated K⁺ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task.

Original language	English (US)
Pages (from-to)	911-912
Number of pages	2
Journal	Nature Neuroscience
Volume	6
Issue number	9
DOIs	https://doi.org/10.1038/nn1101
State	Published - Sep 1 2003
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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AU - Spiess, Joachim

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Small-conductance, Ca²⁺-activated K⁺ channel SK3 generates age-related memory and LTP deficits

Abstract

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