TY - JOUR
T1 - Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma
AU - Ramakrishnan, Gopalakrishnan
AU - Elinos-Báez, Carmen Martha
AU - Jagan, Sundaram
AU - Augustine, Titto Alby
AU - Kamaraj, Sattu
AU - Anandakumar, Pandi
AU - Devaki, Thiruvengadam
PY - 2008/6
Y1 - 2008/6
N2 - Silymarin is a naturally available bioflavonoid and is a strong antioxidant with a capacity to inhibit the formation of tumors in several cancer models. In the present study, we investigated whether dietary supplementation of silymarin has any role in lipid components, lipid-metabolizing enzymes, free fatty acid profile, and expression of cyclooxygenase-2 (COX-2) in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma in rats. NDEA-induced rats showed severe hyperlipidemia along with upregulated expression of COX-2 as revealed by western blotting and immunohistochemistry. Dietary silymarin supplementation attenuated this hyperlipidemia and downregulated the expression of COX-2. Thus we conclude that compounds like silymarin with potent hypolipidemic effect are strong candidates as chemopreventive agents for the treatment of liver cancer.
AB - Silymarin is a naturally available bioflavonoid and is a strong antioxidant with a capacity to inhibit the formation of tumors in several cancer models. In the present study, we investigated whether dietary supplementation of silymarin has any role in lipid components, lipid-metabolizing enzymes, free fatty acid profile, and expression of cyclooxygenase-2 (COX-2) in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma in rats. NDEA-induced rats showed severe hyperlipidemia along with upregulated expression of COX-2 as revealed by western blotting and immunohistochemistry. Dietary silymarin supplementation attenuated this hyperlipidemia and downregulated the expression of COX-2. Thus we conclude that compounds like silymarin with potent hypolipidemic effect are strong candidates as chemopreventive agents for the treatment of liver cancer.
KW - COX-2
KW - HMG-CoAreductase
KW - Hepatocellular carcinoma
KW - Hyperlipidemia
KW - N-nitrosodiethylamine
KW - Silymarin
UR - http://www.scopus.com/inward/record.url?scp=44449096507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44449096507&partnerID=8YFLogxK
U2 - 10.1007/s11010-008-9741-5
DO - 10.1007/s11010-008-9741-5
M3 - Article
C2 - 18373278
AN - SCOPUS:44449096507
SN - 0300-8177
VL - 313
SP - 53
EP - 61
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
IS - 1-2
ER -
