TY - JOUR
T1 - Signal transduction associated with lead-induced neurological disorders
T2 - A review
AU - Fang, Yuanyuan
AU - Lu, Lili
AU - Liang, Yuan
AU - Peng, Dongjie
AU - Aschner, Michael
AU - Jiang, Yueming
N1 - Funding Information:
This study was funded by grants from the National Natural Science Foundation of China ( NSFC 81773476). The authors thank Prof. Zheng Wei from School of Health Sciences, Purdue University for their revision of the manuscript for grammar and style, and useful suggestions.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/4
Y1 - 2021/4
N2 - Lead is a heavy metal pollutant that is widely present in the environment. It affects every organ system, yet the nervous system appears to be the most sensitive and primary target. Although many countries have made significant strides in controlling Pb pollution, Pb poisoning continuous to be a major public health concern. Exposure to Pb causes neurotoxicity that ranges from neurodevelopmental disorders to severe neurodegenerative lesions, leading to impairments in learning, memory, and cognitive function. Studies on the mechanisms of Pb-induced nervous system injury have convincingly shown that this metal can affect a plethora of cellular pathways affecting on cell survival, altering calcium dyshomeostasis, and inducing apoptosis, inflammation, energy metabolism disorders, oxidative stress, autophagy and glial stress. This review summarizes recent knowledge on multiple signaling pathways associated with Pb-induced neurological disorders in vivo and in vitro.
AB - Lead is a heavy metal pollutant that is widely present in the environment. It affects every organ system, yet the nervous system appears to be the most sensitive and primary target. Although many countries have made significant strides in controlling Pb pollution, Pb poisoning continuous to be a major public health concern. Exposure to Pb causes neurotoxicity that ranges from neurodevelopmental disorders to severe neurodegenerative lesions, leading to impairments in learning, memory, and cognitive function. Studies on the mechanisms of Pb-induced nervous system injury have convincingly shown that this metal can affect a plethora of cellular pathways affecting on cell survival, altering calcium dyshomeostasis, and inducing apoptosis, inflammation, energy metabolism disorders, oxidative stress, autophagy and glial stress. This review summarizes recent knowledge on multiple signaling pathways associated with Pb-induced neurological disorders in vivo and in vitro.
KW - Apoptosis
KW - Autophagy
KW - Calcium
KW - Inflammation
KW - Lead
KW - Lead-induced neurotoxicity
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U2 - 10.1016/j.fct.2021.112063
DO - 10.1016/j.fct.2021.112063
M3 - Review article
C2 - 33596455
AN - SCOPUS:85101329442
SN - 0278-6915
VL - 150
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
M1 - 112063
ER -
