Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium

Jessica Gong; Katie Harris; Darren M. Lipnicki; Erico Castro-Costa; Maria Fernanda Lima-Costa; Breno S. Diniz; Shifu Xiao; Richard B. Lipton; Mindy J. Katz; Cuiling Wang; Pierre Marie Preux; Maëlenn Guerchet; Antoine Gbessemehlan; Karen Ritchie; Marie Laure Ancelin; Ingmar Skoog; Jenna Najar; Therese Rydberg Sterner; Nikolaos Scarmeas; Mary Yannakoulia; Mary H. Kosmidis; Antonio Guaita; Elena Rolandi; Annalisa Davin; Oye Gureje; Stella Trompet; Jacobijn Gussekloo; Steffi Riedel-Heller; Alexander Pabst; Susanne Röhr; Suzana Shahar; Devinder Kaur Ajit Singh; Nurul Fatin Malek Rivan; Martin van Boxtel; Sebastian Köhler; Mary Ganguli; Chung Chou Chang; Erin Jacobsen; Mary Haan; Ding Ding; Qianhua Zhao; Zhenxu Xiao; Kenji Narazaki; Tao Chen; Sanmei Chen; Tze Pin Ng; Xinyi Gwee; Katya Numbers; Karen A. Mather; Marcia Scazufca; Antonio Lobo; Concepción De-la-Cámara; Elena Lobo; Perminder S. Sachdev; Henry Brodaty; Maree L. Hackett; Sanne A.E. Peters; Mark Woodward

doi:10.1002/alz.12962

Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium

Jessica Gong, Katie Harris, Darren M. Lipnicki, Erico Castro-Costa, Maria Fernanda Lima-Costa, Breno S. Diniz, Shifu Xiao, Richard B. Lipton, Mindy J. Katz, Cuiling Wang, Pierre Marie Preux, Maëlenn Guerchet, Antoine Gbessemehlan, Karen Ritchie, Marie Laure Ancelin, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary YannakouliaMary H. Kosmidis, Antonio Guaita, Elena Rolandi, Annalisa Davin, Oye Gureje, Stella Trompet, Jacobijn Gussekloo, Steffi Riedel-Heller, Alexander Pabst, Susanne Röhr, Suzana Shahar, Devinder Kaur Ajit Singh, Nurul Fatin Malek Rivan, Martin van Boxtel, Sebastian Köhler, Mary Ganguli, Chung Chou Chang, Erin Jacobsen, Mary Haan, Ding Ding, Qianhua Zhao, Zhenxu Xiao, Kenji Narazaki, Tao Chen, Sanmei Chen, Tze Pin Ng, Xinyi Gwee, Katya Numbers, Karen A. Mather, Marcia Scazufca, Antonio Lobo, Concepción De-la-Cámara, Elena Lobo, Perminder S. Sachdev, Henry Brodaty, Maree L. Hackett, Sanne A.E. Peters, Mark Woodward

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Introduction: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. Methods: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. Results: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. Discussion: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.

Original language	English (US)
Pages (from-to)	3365-3378
Number of pages	14
Journal	Alzheimer's and Dementia
Volume	19
Issue number	8
DOIs	https://doi.org/10.1002/alz.12962
State	Published - Aug 2023

Keywords

data harmonization
dementia
diversity
risk factor
sex difference

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/alz.12962

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Gong, J., Harris, K., Lipnicki, D. M., Castro-Costa, E., Lima-Costa, M. F., Diniz, B. S., Xiao, S., Lipton, R. B., Katz, M. J., Wang, C., Preux, P. M., Guerchet, M., Gbessemehlan, A., Ritchie, K., Ancelin, M. L., Skoog, I., Najar, J., Sterner, T. R., Scarmeas, N., ... Woodward, M. (2023). Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium. Alzheimer's and Dementia, 19(8), 3365-3378. https://doi.org/10.1002/alz.12962

Gong, J, Harris, K, Lipnicki, DM, Castro-Costa, E, Lima-Costa, MF, Diniz, BS, Xiao, S, Lipton, RB , Katz, MJ , Wang, C, Preux, PM, Guerchet, M, Gbessemehlan, A, Ritchie, K, Ancelin, ML, Skoog, I, Najar, J, Sterner, TR, Scarmeas, N, Yannakoulia, M, Kosmidis, MH, Guaita, A, Rolandi, E, Davin, A, Gureje, O, Trompet, S, Gussekloo, J, Riedel-Heller, S, Pabst, A, Röhr, S, Shahar, S, Singh, DKA, Rivan, NFM, Boxtel, MV, Köhler, S, Ganguli, M, Chang, CC, Jacobsen, E, Haan, M, Ding, D, Zhao, Q, Xiao, Z, Narazaki, K, Chen, T, Chen, S, Ng, TP, Gwee, X, Numbers, K, Mather, KA, Scazufca, M, Lobo, A, De-la-Cámara, C, Lobo, E, Sachdev, PS, Brodaty, H, Hackett, ML, Peters, SAE & Woodward, M 2023, 'Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium', Alzheimer's and Dementia, vol. 19, no. 8, pp. 3365-3378. https://doi.org/10.1002/alz.12962

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title = "Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium",

abstract = "Introduction: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. Methods: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. Results: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. Discussion: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.",

keywords = "data harmonization, dementia, diversity, risk factor, sex difference",

author = "Jessica Gong and Katie Harris and Lipnicki, {Darren M.} and Erico Castro-Costa and Lima-Costa, {Maria Fernanda} and Diniz, {Breno S.} and Shifu Xiao and Lipton, {Richard B.} and Katz, {Mindy J.} and Cuiling Wang and Preux, {Pierre Marie} and Ma{\"e}lenn Guerchet and Antoine Gbessemehlan and Karen Ritchie and Ancelin, {Marie Laure} and Ingmar Skoog and Jenna Najar and Sterner, {Therese Rydberg} and Nikolaos Scarmeas and Mary Yannakoulia and Kosmidis, {Mary H.} and Antonio Guaita and Elena Rolandi and Annalisa Davin and Oye Gureje and Stella Trompet and Jacobijn Gussekloo and Steffi Riedel-Heller and Alexander Pabst and Susanne R{\"o}hr and Suzana Shahar and Singh, {Devinder Kaur Ajit} and Rivan, {Nurul Fatin Malek} and Boxtel, {Martin van} and Sebastian K{\"o}hler and Mary Ganguli and Chang, {Chung Chou} and Erin Jacobsen and Mary Haan and Ding Ding and Qianhua Zhao and Zhenxu Xiao and Kenji Narazaki and Tao Chen and Sanmei Chen and Ng, {Tze Pin} and Xinyi Gwee and Katya Numbers and Mather, {Karen A.} and Marcia Scazufca and Antonio Lobo and Concepci{\'o}n De-la-C{\'a}mara and Elena Lobo and Sachdev, {Perminder S.} and Henry Brodaty and Hackett, {Maree L.} and Peters, {Sanne A.E.} and Mark Woodward",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2023",

month = aug,

doi = "10.1002/alz.12962",

language = "English (US)",

volume = "19",

pages = "3365--3378",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

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T1 - Sex differences in dementia risk and risk factors

T2 - Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium

AU - Gong, Jessica

AU - Harris, Katie

AU - Lipnicki, Darren M.

AU - Castro-Costa, Erico

AU - Lima-Costa, Maria Fernanda

AU - Diniz, Breno S.

AU - Xiao, Shifu

AU - Lipton, Richard B.

AU - Katz, Mindy J.

AU - Wang, Cuiling

AU - Preux, Pierre Marie

AU - Guerchet, Maëlenn

AU - Gbessemehlan, Antoine

AU - Ritchie, Karen

AU - Ancelin, Marie Laure

AU - Skoog, Ingmar

AU - Najar, Jenna

AU - Sterner, Therese Rydberg

AU - Scarmeas, Nikolaos

AU - Yannakoulia, Mary

AU - Kosmidis, Mary H.

AU - Guaita, Antonio

AU - Rolandi, Elena

AU - Davin, Annalisa

AU - Gureje, Oye

AU - Trompet, Stella

AU - Gussekloo, Jacobijn

AU - Riedel-Heller, Steffi

AU - Pabst, Alexander

AU - Röhr, Susanne

AU - Shahar, Suzana

AU - Singh, Devinder Kaur Ajit

AU - Rivan, Nurul Fatin Malek

AU - Boxtel, Martin van

AU - Köhler, Sebastian

AU - Ganguli, Mary

AU - Chang, Chung Chou

AU - Jacobsen, Erin

AU - Haan, Mary

AU - Ding, Ding

AU - Zhao, Qianhua

AU - Xiao, Zhenxu

AU - Narazaki, Kenji

AU - Chen, Tao

AU - Chen, Sanmei

AU - Ng, Tze Pin

AU - Gwee, Xinyi

AU - Numbers, Katya

AU - Mather, Karen A.

AU - Scazufca, Marcia

AU - Lobo, Antonio

AU - De-la-Cámara, Concepción

AU - Lobo, Elena

AU - Sachdev, Perminder S.

AU - Brodaty, Henry

AU - Hackett, Maree L.

AU - Peters, Sanne A.E.

AU - Woodward, Mark

PY - 2023/8

Y1 - 2023/8

N2 - Introduction: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. Methods: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. Results: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. Discussion: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.

AB - Introduction: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. Methods: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. Results: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. Discussion: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.

KW - data harmonization

KW - dementia

KW - diversity

KW - risk factor

KW - sex difference

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DO - 10.1002/alz.12962

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SN - 1552-5260

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Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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