Sex-dependent maturation of GABAA receptor-mediated synaptic events in rat substantia nigra reticulata

Andreas Kyrozis; Ondrej Chudomel; Solomon L. Moshé; Aristea S. Galanopoulou

doi:10.1016/j.neulet.2005.12.018

Sex-dependent maturation of GABA_A receptor-mediated synaptic events in rat substantia nigra reticulata

Andreas Kyrozis, Ondrej Chudomel, Solomon L. Moshé, Aristea S. Galanopoulou

Neurology

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

The substantia nigra pars reticulata (SNR) plays important roles in movement and, in an age- and sex-dependent manner, in seizure control. GABAergic synaptic transmission is critical in both normal development and seizures. In many neuronal types it is excitatory early in development and later switches to the mature hyperpolarizing type. We assessed the time course of the switch of GABA_A receptor-mediated postsynaptic currents (PSCs) in anterior SNR neurons of male and female developing rats using the gramicidin perforated patch clamp technique. The switch occurred in males around postnatal day (PN) 17 and in females around PN10. This sex dimorphism may play a role in several other recognized sex differences in the development of SNR and in its regulatory role in seizures.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Neuroscience Letters
Volume	398
Issue number	1-2
DOIs	https://doi.org/10.1016/j.neulet.2005.12.018
State	Published - May 1 2006

Keywords

Calcium
Chloride
Epilepsy
KCC2
PSP
Postsynaptic potentials
Potassium-chloride cotransporter

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neulet.2005.12.018

Cite this

@article{87a25713da7041339f4a05de22d94d65,

title = "Sex-dependent maturation of GABAA receptor-mediated synaptic events in rat substantia nigra reticulata",

abstract = "The substantia nigra pars reticulata (SNR) plays important roles in movement and, in an age- and sex-dependent manner, in seizure control. GABAergic synaptic transmission is critical in both normal development and seizures. In many neuronal types it is excitatory early in development and later switches to the mature hyperpolarizing type. We assessed the time course of the switch of GABAA receptor-mediated postsynaptic currents (PSCs) in anterior SNR neurons of male and female developing rats using the gramicidin perforated patch clamp technique. The switch occurred in males around postnatal day (PN) 17 and in females around PN10. This sex dimorphism may play a role in several other recognized sex differences in the development of SNR and in its regulatory role in seizures.",

keywords = "Calcium, Chloride, Epilepsy, KCC2, PSP, Postsynaptic potentials, Potassium-chloride cotransporter",

author = "Andreas Kyrozis and Ondrej Chudomel and Mosh{\'e}, {Solomon L.} and Galanopoulou, {Aristea S.}",

note = "Funding Information: We thank Anna Lee for helping optimize the experimental setup; Jana Veliskova and Libor Velisek for critical reading of the manuscript. Supported by NIH NS-20253, NS-45243, Rett Syndrome Research Foundation, Heffer Family Foundation. SLM is the recipient of a Martin A. and Emily L. Fisher fellowship in Neurology and Pediatrics.",

year = "2006",

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AU - Kyrozis, Andreas

AU - Chudomel, Ondrej

AU - Moshé, Solomon L.

AU - Galanopoulou, Aristea S.

N1 - Funding Information: We thank Anna Lee for helping optimize the experimental setup; Jana Veliskova and Libor Velisek for critical reading of the manuscript. Supported by NIH NS-20253, NS-45243, Rett Syndrome Research Foundation, Heffer Family Foundation. SLM is the recipient of a Martin A. and Emily L. Fisher fellowship in Neurology and Pediatrics.

PY - 2006/5/1

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N2 - The substantia nigra pars reticulata (SNR) plays important roles in movement and, in an age- and sex-dependent manner, in seizure control. GABAergic synaptic transmission is critical in both normal development and seizures. In many neuronal types it is excitatory early in development and later switches to the mature hyperpolarizing type. We assessed the time course of the switch of GABAA receptor-mediated postsynaptic currents (PSCs) in anterior SNR neurons of male and female developing rats using the gramicidin perforated patch clamp technique. The switch occurred in males around postnatal day (PN) 17 and in females around PN10. This sex dimorphism may play a role in several other recognized sex differences in the development of SNR and in its regulatory role in seizures.

AB - The substantia nigra pars reticulata (SNR) plays important roles in movement and, in an age- and sex-dependent manner, in seizure control. GABAergic synaptic transmission is critical in both normal development and seizures. In many neuronal types it is excitatory early in development and later switches to the mature hyperpolarizing type. We assessed the time course of the switch of GABAA receptor-mediated postsynaptic currents (PSCs) in anterior SNR neurons of male and female developing rats using the gramicidin perforated patch clamp technique. The switch occurred in males around postnatal day (PN) 17 and in females around PN10. This sex dimorphism may play a role in several other recognized sex differences in the development of SNR and in its regulatory role in seizures.

KW - Calcium

KW - Chloride

KW - Epilepsy

KW - KCC2

KW - PSP

KW - Postsynaptic potentials

KW - Potassium-chloride cotransporter

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