Serial analysis of gene expression: Technical considerations and applications to cardiovascular biology

Willmar D. Patino; Omar Y. Mian; Paul M. Hwang; Gordon F. Tomaselli

doi:10.1161/01.RES.0000036018.76903.18

Serial analysis of gene expression: Technical considerations and applications to cardiovascular biology

Willmar D. Patino, Omar Y. Mian, Paul M. Hwang, Gordon F. Tomaselli

Research output: Contribution to journal › Short survey › peer-review

40 Scopus citations

Abstract

It has been 7 years since serial analysis of gene expression (SAGE) and microarray hybridization techniques were simultaneously introduced to allow the screening of thousands of expressed genes. Both techniques have stood up to the test of time as evidenced by their widespread use, and both have been used for studying cardiovascular diseases. SAGE has been used more extensively to study cancer cells, but it has also been used to examine gene expression in systems as divergent as rice seedlings, yeast, and Caenorhabditis elegans. In this review, a summary of the advances in SAGE technology and its unique attributes and potential applications to the cardiovascular system will be presented.

Original language	English (US)
Pages (from-to)	565-569
Number of pages	5
Journal	Circulation research
Volume	91
Issue number	7
DOIs	https://doi.org/10.1161/01.RES.0000036018.76903.18
State	Published - Oct 4 2002
Externally published	Yes

Keywords

Cardiovascular
Expression
Gene

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/01.RES.0000036018.76903.18

Cite this

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title = "Serial analysis of gene expression: Technical considerations and applications to cardiovascular biology",

abstract = "It has been 7 years since serial analysis of gene expression (SAGE) and microarray hybridization techniques were simultaneously introduced to allow the screening of thousands of expressed genes. Both techniques have stood up to the test of time as evidenced by their widespread use, and both have been used for studying cardiovascular diseases. SAGE has been used more extensively to study cancer cells, but it has also been used to examine gene expression in systems as divergent as rice seedlings, yeast, and Caenorhabditis elegans. In this review, a summary of the advances in SAGE technology and its unique attributes and potential applications to the cardiovascular system will be presented.",

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AU - Patino, Willmar D.

AU - Mian, Omar Y.

AU - Hwang, Paul M.

AU - Tomaselli, Gordon F.

PY - 2002/10/4

Y1 - 2002/10/4

N2 - It has been 7 years since serial analysis of gene expression (SAGE) and microarray hybridization techniques were simultaneously introduced to allow the screening of thousands of expressed genes. Both techniques have stood up to the test of time as evidenced by their widespread use, and both have been used for studying cardiovascular diseases. SAGE has been used more extensively to study cancer cells, but it has also been used to examine gene expression in systems as divergent as rice seedlings, yeast, and Caenorhabditis elegans. In this review, a summary of the advances in SAGE technology and its unique attributes and potential applications to the cardiovascular system will be presented.

AB - It has been 7 years since serial analysis of gene expression (SAGE) and microarray hybridization techniques were simultaneously introduced to allow the screening of thousands of expressed genes. Both techniques have stood up to the test of time as evidenced by their widespread use, and both have been used for studying cardiovascular diseases. SAGE has been used more extensively to study cancer cells, but it has also been used to examine gene expression in systems as divergent as rice seedlings, yeast, and Caenorhabditis elegans. In this review, a summary of the advances in SAGE technology and its unique attributes and potential applications to the cardiovascular system will be presented.

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JO - Circulation Research

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Serial analysis of gene expression: Technical considerations and applications to cardiovascular biology

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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