Sensitivityof 3-Dimensional sonography in preoperativeevaluationofparathyroid glands inpatients with primary hyperparathyroidism

Susan J. Frank, Adam E. Goldman-Yassen, Tova Koenigsberg, Steven K. Libutti, Mordecai Koenigsberg

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objectives—Preoperative localization of parathyroid adenomas in patients with primary hyperparathyroidism facilitates targeted surgery. We assessed the sensitivity of 3-dimensional (3D) sonography for preoperative localization of abnormal parathyroid glands. Methods—We conducted a retrospective review of patients who underwent parathyroidectomy for primary hyperparathyroidism at a single site at our institution. We compared preoperative 2-dimensional (2D) sonography, 3D sonography, and sestamibi scans with final gland localization at surgery. Two readers reviewed the sonograms to assess inter-reader variability. Results—From January 2010 through April 2015, 52 patients underwent parathyroidectomy after preoperative 2D sonography, 3D sonography, and sestamibi scans. Three-dimensional sonography had sensitivity of 88–92% compared with 69–71% for 2D sonography for gland localization. In patients in whom sonography and sestamibi scans localized abnormalities to the same side, the sensitivities were 100% (43 of 43) for 3D sonography and 96% (48 of 50) for 2D sonography. Threedimensional sonography had significantly higher sensitivity for localization of glands smaller than 500 mg compared with 2D sonography (88% versus 58%; P5.012). There was better inter-reader agreement between the radiologists when using 3D sonography (j50.65) compared with 2D sonography (j50.41). Conclusions—We found a significantly higher sensitivity and better inter-reader agreement for 3D sonography compared with 2D sonography for preoperative identification of abnormal parathyroid glands, especially among smaller glands.

Original languageEnglish (US)
Pages (from-to)1897-1904
Number of pages8
JournalJournal of Ultrasound in Medicine
Issue number9
StatePublished - Sep 2017


  • 3-Dimensional sonography
  • Head and neck ultrasound
  • Hyperparathyroidism
  • Parathyroid adenoma

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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