Seizure clustering

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations


Seizure clusters, also known as repetitive or serial seizures, occur commonly in epilepsy. Clustering implies that the occurrence of one seizure may influence the probability of a subsequent seizure; thus, the investigation of the clustering phenomenon yields insights into both specific mechanisms of seizure clustering and more general concepts of seizure occurrence. Seizure clustering has been defined clinically as a number of seizures per unit time and, statistically, as a deviation from a random distribution, or interseizure interval dependence. This review explores the pathophysiology, epidemiology, and clinical implications of clustering, as well as other periodic patterns of seizure occurrence. Risk factors for experiencing clusters and potential precipitants of clustering are also addressed.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalEpilepsy and Behavior
Issue number1
StatePublished - Feb 2006


  • Acute repetitive seizures
  • Cluster
  • Intractable epilepsy
  • Poisson
  • Seizure clustering
  • Serial seizures
  • Status epilepticus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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