Sarcomatous transformation of the orbit in a patient with Paget's disease

Sharon Goldberg; Thomas L. Slamovits; Howard D. Dorfman; Pearl S. Rosenbaum

doi:10.1016/S0161-6420(00)00180-9

Sarcomatous transformation of the orbit in a patient with Paget's disease

Sharon Goldberg, Thomas L. Slamovits, Howard D. Dorfman, Pearl S. Rosenbaum

Ophthalmology & Visual Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Objective: To report the clinical and pathologic features of sarcomatous transformation of the skull with involvement of the orbit, in Paget's disease. Design: Interventional case report. Participant: An 83-year-old woman with Paget's disease who experienced progressive proptosis of the left eye. Intervention: Fine-needle aspiration biopsy of the orbital mass. Results: Cytologic examination revealed round to oval malignant cells with wispy cytoplasm, consistent with the diagnosis of sarcoma. The patient died shortly after institution of orbital radiation therapy and systemic steroid therapy. Conclusions: Proptosis related to Paget's disease is uncommon, and only rarely is it a result of sarcomatous transformation. Sarcomatous transformation of the skull involving the orbit should be included in the differential diagnosis of progressive proptosis in patients with Paget's disease. (C) 2000 by the American Academy of Ophthalmology.

Original language	English (US)
Pages (from-to)	1464-1467
Number of pages	4
Journal	Ophthalmology
Volume	107
Issue number	8
DOIs	https://doi.org/10.1016/S0161-6420(00)00180-9
State	Published - 2000

ASJC Scopus subject areas

Ophthalmology

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title = "Sarcomatous transformation of the orbit in a patient with Paget's disease",

abstract = "Objective: To report the clinical and pathologic features of sarcomatous transformation of the skull with involvement of the orbit, in Paget's disease. Design: Interventional case report. Participant: An 83-year-old woman with Paget's disease who experienced progressive proptosis of the left eye. Intervention: Fine-needle aspiration biopsy of the orbital mass. Results: Cytologic examination revealed round to oval malignant cells with wispy cytoplasm, consistent with the diagnosis of sarcoma. The patient died shortly after institution of orbital radiation therapy and systemic steroid therapy. Conclusions: Proptosis related to Paget's disease is uncommon, and only rarely is it a result of sarcomatous transformation. Sarcomatous transformation of the skull involving the orbit should be included in the differential diagnosis of progressive proptosis in patients with Paget's disease. (C) 2000 by the American Academy of Ophthalmology.",

author = "Sharon Goldberg and Slamovits, {Thomas L.} and Dorfman, {Howard D.} and Rosenbaum, {Pearl S.}",

note = "Funding Information: Supported in part by an unrestricted grant to the Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Montefiore Medical Center from Research to Prevent Blindness, Inc., New York, New York. ",

year = "2000",

doi = "10.1016/S0161-6420(00)00180-9",

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pages = "1464--1467",

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T1 - Sarcomatous transformation of the orbit in a patient with Paget's disease

AU - Goldberg, Sharon

AU - Slamovits, Thomas L.

AU - Dorfman, Howard D.

AU - Rosenbaum, Pearl S.

N1 - Funding Information: Supported in part by an unrestricted grant to the Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Montefiore Medical Center from Research to Prevent Blindness, Inc., New York, New York.

PY - 2000

Y1 - 2000

N2 - Objective: To report the clinical and pathologic features of sarcomatous transformation of the skull with involvement of the orbit, in Paget's disease. Design: Interventional case report. Participant: An 83-year-old woman with Paget's disease who experienced progressive proptosis of the left eye. Intervention: Fine-needle aspiration biopsy of the orbital mass. Results: Cytologic examination revealed round to oval malignant cells with wispy cytoplasm, consistent with the diagnosis of sarcoma. The patient died shortly after institution of orbital radiation therapy and systemic steroid therapy. Conclusions: Proptosis related to Paget's disease is uncommon, and only rarely is it a result of sarcomatous transformation. Sarcomatous transformation of the skull involving the orbit should be included in the differential diagnosis of progressive proptosis in patients with Paget's disease. (C) 2000 by the American Academy of Ophthalmology.

AB - Objective: To report the clinical and pathologic features of sarcomatous transformation of the skull with involvement of the orbit, in Paget's disease. Design: Interventional case report. Participant: An 83-year-old woman with Paget's disease who experienced progressive proptosis of the left eye. Intervention: Fine-needle aspiration biopsy of the orbital mass. Results: Cytologic examination revealed round to oval malignant cells with wispy cytoplasm, consistent with the diagnosis of sarcoma. The patient died shortly after institution of orbital radiation therapy and systemic steroid therapy. Conclusions: Proptosis related to Paget's disease is uncommon, and only rarely is it a result of sarcomatous transformation. Sarcomatous transformation of the skull involving the orbit should be included in the differential diagnosis of progressive proptosis in patients with Paget's disease. (C) 2000 by the American Academy of Ophthalmology.

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JO - Ophthalmology

JF - Ophthalmology

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ER -

Sarcomatous transformation of the orbit in a patient with Paget's disease

Abstract

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