Abstract
Alcohol (ethanol), presumably consumed as wine as far back as 7000 BC, is most likely the first addictive substance known to man. In modern days, its abuse leading to neurotoxicity and a myriad of organ damages, is of considerable social and medical concern. In the United States alone, approximately 180,000 people die yearly because of alcohol-related accidents and diseases. Given its ubiquitous nature, alcohol may interact with many cellular components. In this chapter, we specifically concentrate on its neurotoxic mechanisms involving glial cells and their role in neuroinflammation. Moreover, exploitation of this knowledge for potential novel interventions in alcohol-induced neurotoxicity are touched upon.
| Original language | English (US) |
|---|---|
| Title of host publication | Neurotoxicity of Solvents |
| Editors | Christoph Van Thriel |
| Publisher | Elsevier Inc. |
| Pages | 41-73 |
| Number of pages | 33 |
| ISBN (Print) | 9780443343285 |
| DOIs | |
| State | Published - Jan 2025 |
Publication series
| Name | Advances in Neurotoxicology |
|---|---|
| Volume | 14 |
| ISSN (Electronic) | 2468-7480 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Alcohol
- Alcohol use disorder (AUD)
- Astrocytes
- Ependymal cells
- Ethanol
- Glial cells
- Microglia
- Neuroinflammation
- Neurotoxicity
- Synantocytes
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Health, Toxicology and Mutagenesis
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