Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Leila Alland; Rebecca Muhle; Harry Hou; Jason Potes; Lynda Chin; Nicole Schreiber-Agus; Ronald A. DePinho

doi:10.1038/387049a0

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Leila Alland, Rebecca Muhle, Harry Hou, Jason Potes, Lynda Chin, Nicole Schreiber-Agus, Ronald A. DePinho

Cell Biology

Research output: Contribution to journal › Article › peer-review

743 Scopus citations

Abstract

Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxl1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxl1/Sin3-induced transcriptional repression and tumour suppression.

Original language	English (US)
Pages (from-to)	49-55
Number of pages	7
Journal	Nature
Volume	387
Issue number	6628
DOIs	https://doi.org/10.1038/387049a0
State	Published - May 1 1997

ASJC Scopus subject areas

General

Access to Document

10.1038/387049a0

Cite this

@article{775b3f7373e848d9aac53a712cc70903,

title = "Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression",

abstract = "Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxl1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxl1/Sin3-induced transcriptional repression and tumour suppression.",

author = "Leila Alland and Rebecca Muhle and Harry Hou and Jason Potes and Lynda Chin and Nicole Schreiber-Agus and DePinho, {Ronald A.}",

year = "1997",

month = may,

day = "1",

doi = "10.1038/387049a0",

language = "English (US)",

volume = "387",

pages = "49--55",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "6628",

}

TY - JOUR

T1 - Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

AU - Alland, Leila

AU - Muhle, Rebecca

AU - Hou, Harry

AU - Potes, Jason

AU - Chin, Lynda

AU - Schreiber-Agus, Nicole

AU - DePinho, Ronald A.

PY - 1997/5/1

Y1 - 1997/5/1

N2 - Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxl1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxl1/Sin3-induced transcriptional repression and tumour suppression.

AB - Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxl1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxl1/Sin3-induced transcriptional repression and tumour suppression.

UR - http://www.scopus.com/inward/record.url?scp=0030959244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030959244&partnerID=8YFLogxK

U2 - 10.1038/387049a0

DO - 10.1038/387049a0

M3 - Article

C2 - 9139821

AN - SCOPUS:0030959244

SN - 0028-0836

VL - 387

SP - 49

EP - 55

JO - Nature

JF - Nature

IS - 6628

ER -

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this