Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Leila Alland; Rebecca Muhle; Harry Hou; Jason Potes; Lynda Chin; Nicole Schreiber-Agus; Ronald A. DePinho

doi:10.1038/387049a0

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Leila Alland, Rebecca Muhle, Harry Hou, Jason Potes, Lynda Chin, Nicole Schreiber-Agus, Ronald A. DePinho

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxl1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxl1/Sin3-induced transcriptional repression and tumour suppression.

Original language	English (US)
Pages (from-to)	49-55
Number of pages	7
Journal	Nature
Volume	387
Issue number	6628
DOIs	https://doi.org/10.1038/387049a0
State	Published - May 1 1997
Externally published	Yes

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title = "Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression",

abstract = "Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxl1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxl1/Sin3-induced transcriptional repression and tumour suppression.",

author = "Leila Alland and Rebecca Muhle and Harry Hou and Jason Potes and Lynda Chin and Nicole Schreiber-Agus and DePinho, {Ronald A.}",

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AU - Alland, Leila

AU - Muhle, Rebecca

AU - Hou, Harry

AU - Potes, Jason

AU - Chin, Lynda

AU - Schreiber-Agus, Nicole

AU - DePinho, Ronald A.

PY - 1997/5/1

Y1 - 1997/5/1

N2 - Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxl1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxl1/Sin3-induced transcriptional repression and tumour suppression.

AB - Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxl1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxl1/Sin3-induced transcriptional repression and tumour suppression.

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JO - Nature

JF - Nature

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ER -

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Abstract

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