Role for mycobacterium tuberculosis membrane vesicles in iron acquisition

Rafael Prados-Rosales, Brian C. Weinrick, Daniel G. Piqué, William R. Jacobs, Arturo Casadevall, G. Marcela Rodriguez

Research output: Contribution to journalArticlepeer-review

141 Scopus citations


Mycobacterium tuberculosis releases membrane vesicles packed with molecules that can modulate the immune response. Because environmental conditions often influence the production and content of bacterial vesicles, this study examined M. tuberculosis microvesicles released under iron limitation, a common condition faced by pathogens inside the host. The findings indicate that M. tuberculosis increases microvesicle production in response to iron restriction and that these microvesicles contain mycobactin, which can serve as an iron donor and supports replication of iron-starved mycobacteria. Consequently, the results revealed a role of microvesicles in iron acquisition in M. tuberculosis, which can be critical for survival in the host.

Original languageEnglish (US)
Pages (from-to)1250-1256
Number of pages7
JournalJournal of Bacteriology
Issue number6
StatePublished - Mar 2014

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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